INTRODUCTION Youth Excel was a 3-year pan-Canadian initiative to advance youth health through improving knowledge development and exchange (KDE) capacity. KDE capacity refers to an improvement cycle linking evidence and action. Capacities include local surveillance of youth behaviours; knowledge exchange; skills, resources and a supportive environment to use knowledge; and evaluation. METHODS...

Self-assembly of the amyloid β peptide (Aβ) is strongly linked to the pathogenesis of Alzheimer's disease. Modulation of this aggregation process by small molecule compounds has been shown to potentially inhibit or redirect this process. Thus, a detailed understanding of the mechanism of action of such aggregation modulators is crucial for speci c design of therapeutics against amyloidosis dise...

INTRODUCTION Guillain-Barré syndrome (GBS) is the most frequent cause of acute flaccid paralysis and, despite treatment, there continues to be an associated mortality and severe disability ranging from 9 to 17%. This article reviews the rationale behind the existing immunotherapy in GBS and discusses the future direction that work in this area should follow. AREAS COVERED The pathogenesis of ...

Previous observations (1, 2) have emphasized that potassium is bound to liver mitochondria in a manner that permits exchange with potassium ions in the surrounding fluid but not displacement by sodium ions. This bound electrolyte is not removed by treatment with isotonic sucrose solution. The same picture has been demonstrated in preparations of fragmented mitochondria (2), suggesting it adhere...

Ras mutations are the oncogenic drivers of many human cancers and yet there are still no approved Ras-targeted cancer therapies. Inhibition of Ras nucleotide exchange is a promising new approach but better understanding of this mechanism of action is needed. Here we describe an antibody mimetic, DARPin K27, which inhibits nucleotide exchange of Ras. K27 binds preferentially to the inactive Ras ...

Few evaluation tools are available to assess knowledge-transfer and exchange interventions. The objective of this paper is to develop and demonstrate a theory-based knowledge-transfer and exchange method of evaluation (KEME) that synthesizes 3 theoretical frameworks: the promoting action on research implementation of health services (PARiHS) model, the transtheoretical model of change, and a mo...

The study of Hebrew narratives has generally shown in modern scholarship the intriguing artistry of the biblical stories. However, the apparent simplicity of the angry scenes has not generated significant engagement of its representations. Against this backdrop, the present study describes the consistent literary patterns in the representation of angry scenes in Hebrew narrative, and particular...

The presence of a detectable Ca current during the excitation of a cardiac fiber implies that the Ca lost during the resting interval of the duty cycle must also be detectable. Ca outward movement appears to be effected by Na/Ca exchange when more Na enters than Ca leaves per cycle, thus making the mechanism electrogenic. Since Na/Ca exchange can move Ca either inward or outward depending on th...

The information age has given way to what many military experts are describing as the next major military advancement – Network Centric Warfare (NCW). At its core, NCW has as its objective the translation of information superiority to supreme combat power; providing unprecedented lethality, survivability, and situational awareness to battle commanders and battle staff. One of the challenges ass...

INTRODUCTION Leptospirosis presents with disease of variable severity; multi-organ failure can occur. In this situation, plasma exchange has been used with positive results, although the mechanism of action has not been fully explained. CASE PRESENTATION A 67-year-old Caucasian man developed severe leptospirosis with marked icterus, acute kidney injury and cardiorespiratory failure, after exp...