The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity. The fundamental importance of this protein in mounting an immune response has made it an attractive target for immunomodulation. Several studies have demonstrated that CD154 expression is regulated at the level of mRNA turnover in a manner distinct from other cytokine genes. W...

Background & aim: The prevalence rate of contraceptive use in Ethiopia is 42%; however, only 5% of Ethiopians use the long-acting contraceptive methods. This rate is 4.8% in Benishangul Gumuz Region in this country. Regarding this, the present study aimed to assess the determinants of long-acting reversible contraceptive method use among married women in Assosa town, E...

We consider the aff(1)-module structure on the spaces of bilinear differential operators acting on the spaces of weighted densities. We compute the first differential cohomology of the Lie superalgebra aff(1) with coefficients in space Dλ,ν;µ of bilinear differential operators acting on weighted densities. We study also the super analogue of this problem getting the same results.

Recent progress in large-scale sequencing, genomics, and rapid gene isolation techniques has accelerated the identification of race-specific resistance ( R ) genes their corresponding avirulence Avr wheat, barley, rye, wild relatives. Here, we describe growing repertoire identified with special emphasis on novel architectures, revealing that there is a large diversity proteins encoded by extend...

Patterns of selection acting on immune defence genes have recently been the focus of considerable interest. Yet, when it comes to vertebrates, studies have mainly focused on the acquired branch of the immune system. Consequently, the direction and strength of selection acting on genes of the vertebrate innate immune defence remain poorly understood. Here, we present a molecular analysis of sele...

Children with language impairment have been found to show limited usage of infinitival complements, one of the earliest complex sentence types to emerge and a significant form in school-age language. Children's production of infinitival complements in conversation is not sufficient to tell us what they know about this form. This article describes a story completion procedure for eliciting infin...

Abstract IL-9 has lent its numerical designation to the Th9 subset of CD4+ Th cells, although it is also produced by additional cell types, including mast cells. It a pleiotropic cytokine involved in allergic reactions, parasitic infections, autoimmune inflammation, and cancer immunity. In this article, we provide evidence that NFATc2 contradictory functions expression murine cells bone marrow–...

緒 言 1916年Smithが マウスにおい て下垂体剔出時, その甲状腺が萎縮する事実 より下垂体には甲状腺 刺激作用のあること を推論 し,1929年 にはLoeb らがその作用物質,即 ち甲状腺刺激ホルモン(T sx)の 抽出に成功するに及び下垂体 と甲状腺の 有機的 な関連性が注目されるに至つた.更 にこの 後Aronら が下垂体のTSH分 泌 は 循環血中の甲 状腺ホルモン(以 下 「甲ホ」 と略)量 に よって調 節され るこ と,即 ち両者間にfeedback relation が存す ることを認めて以来,こ れが甲状腺機能調 節機構の主軸 をなすと考 えられる様 になつた. 各 種 甲状 腺 疾 宙、々 者 に お け るBMR,PBI, 或 い は1311摂 取 率 等 に よ る 機 能 検 査 は 日常routlne に 行 なわ れ て い る が,一 歩 進...

PHARMAC aims to ensure fair allocation of funding across competing new medicines, and must ensure appropriate targeting of medicines to get best value for money. For this reason, our processes for assessing new pharmaceutical funding applications are necessarily diligent. PHARMAC’s process involves both expert clinical review, negotiation with suppliers, consultation with the health sector, and...

Effective treatment decisions sometimes require substantial risk of short-term harm, which can be shown after-the-fact to have been preventable, thereby carrying some liability risk. To err on the side of short-term comfort or safety, however, may greatly increase the overall and long-term risks. For instance, to intrusively restrain a borderline patient from threatened acting out, may (1) fuel...