BACKGROUND There is considerable interest from a regulatory and public health perspective in harmful and potentially harmful constituents in tobacco products, including smokeless tobacco products (STPs). A wide range of commercial STPs from the US and Sweden, representing 80-90 % of the 2010 market share for all the major STP categories in these two countries, were analysed for the IARC Group 2...

Acrylamide has been designated by IARC as a "probable human carcinogen." High levels are formed during cooking of many commonly consumed foods including French fries, potato chips, breakfast cereal and coffee. Two prospective cohort studies and two case-control studies in Europe found no association between acrylamide intake and prostate cancer. We examined this association in a large prospecti...

As acrylamide is a known neurotoxin for many animals and potential carcinogen for humans, it came as a surprise when the Swedish National Food Agency and Stockholm University reported in 2002 that it is formed during the frying or baking of foods. We report here genomic and proteomic analyses on genes and proteins of Caenorhabditis elegans exposed to 500 mg/l acrylamide. Of the 21,120 genes pro...

Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been associated with impaired spermatogenesis and adverse effects on reproductive health. We previously reported that chronic exposure to the reprod...

Genotoxic effects of acrylamide are supposed to result from oxidative biotransformation to glycidamide. After incubation of rat liver slices with acrylamide we detected free glycidamide using a liquid chromatography tandem mass spectrometric method. Glycidamide formation was diminished in the presence of the cytochrome P450 2E1 inhibitor diallyl sulfide (DAS), which is a specific ingredient of ...

A series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Furfurylamine containing indolyl acrylamide derivative 5h exhibited the most potent DGAT inhibitory activity using microsomes prepared from rat liver. Further evaluation against human DGAT-1 and DGAT-2 identified indolyl acrylamide analogues as selective inhibitors against h...

Acrylamide formation in carbohydrate-rich botanical powders consumed Korea was investigated this study. Free asparagine and monosaccharide contents were measured as the chief precursors to acrylamide formation. The highest levels of detected heated lotus roots, followed by potatoes, Jerusalem artichokes, yams. Tubers rhizomes contained more than sugar had a high ratio free amino acids. formed p...

: fried products derived from potato, particularly potato crisp have been widely included in food basket of the households in the recent years in iran. potato crisp, among other products, is of great importance and is considered as competitive products. this product is in the list of the food products with high acrylamide content. therefore, due to the nutritional importance of this product and...

nloaded kground: Acrylamide is a probable human carcinogen formed during cooking of many common foods. miologic studies on acrylamide and breast cancer risk have been null; however, positive associations varian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, etrial, and ovarian cancers in a prospective cohort study. thods: We assessed acrylamide int...