A 4-year-old boy presented with mildly itchy hyperkeratotic scaly lesions on pressure points like knees, elbows, buttocks and ankles in a bilateral symmetrical manner for two months (Fig. 1). Parents also complained of recent onset lethargy and diarrhea for three weeks. Child and parents both were known to be HIVseropositive and were on anti-retroviral therapy. Rest of the mucocutaneous examina...

I was born in 1927. That was the year Charles Lindbergh flew to Paris and Babe Ruth hit 60 home runs. These high points remain vivid in my memory. Later, however, I became aware of two other happenings that plunged hundreds of my human brothers and sisters into a terrible dark and dismal slough of despondance. In 1927, Hitler wrote Mein Kampf (My Struggle). In it he called for the cleansing of ...

The effects of depressed mothers' touching on their infants' behavior were investigated during the still-face situation. 48 depressed and nondepressed mothers and their 3-month-old infants were randomly assigned to control and experimental conditions. 4 successive 90-sec periods were implemented: (A) normal play, (B) still-face-no-touch, (C) still-face-with-touch, and (A) normal play. Depressed...

The classic moral stories have been used extensively to teach children about the consequences of lying and the virtue of honesty. Despite their widespread use, there is no evidence whether these stories actually promote honesty in children. This study compared the effectiveness of four classic moral stories in promoting honesty in 3- to 7-year-olds. Surprisingly, the stories of "Pinocchio" and ...

AIM To examine healthcare resource utilization patterns and costs accrued by carcinoid syndrome (CS) patients with and without diarrhea. METHODS We conducted a retrospective cohort study using MarketScan® data from 1/1/2002-12/31/2012. Newly diagnosed CS patients had 1 medical claim for CS (ICD-9-CM code 259.2) plus either ≥ 1 additional claim for CS or for carcinoid tumors (ICD-9-CM 209.x), ...

PURPOSE New molecular targeted agents are needed for patients with non-small-cell lung cancer (NSCLC) who progress while receiving erlotinib, gefitinib, or both. Afatinib, an oral irreversible ErbB family blocker, has preclinical activity in epidermal growth factor receptor (EGFR [ErbB1]) mutant models with EGFR-activating mutations, including T790M. PATIENTS AND METHODS This was a Japanese s...

BACKGROUND Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea. OBJECTIVE We sought to measure the effect of supplemental zinc given with oral rehydration therapy during recovery from acute or persistent diarrhea. DESIGN We conducted pooled analyses including all available published and unpublished randomized controll...

INTRODUCTION Diarrhea is a common complication of acquired immune deficiency syndrome (AIDS), occurring in almost 90% of AIDS patients in developing countries like India. The present study was aimed to determine the prevalence and microbiological profile of pathogens associated with diarrhea in human immunodeficiency virus (HIV) positive patients and their relation to CD4 counts. MATERIALS AN...

The swine leukocyte antigen (SLA)-DRA locus is noteworthy among other SLA class II loci for its limited variation and has not been investigated in depth. This study was investigated to detect polymorphisms of four exons of SLA-DRA gene and its association with piglet diarrhea in Landrace, Large White and Duroc pigs. No polymorphisms were detected in exon 3, while 2 SNPs (c.178G>A and c.211T>C),...