BACKGROUND & OBJECTIVES Carbapenem-resistant Acinetobacter spp. have gained increasing significance as opportunistic pathogens in hospitalized patients. Carbapenem resistance is often associated with the loss and/or decrease in outer membrane proteins (OMP) and overexpression of multidrug efflux systems. However, carbapenem-hydrolysing beta-lactamases of Ambler Class B (metallo-enzymes) and Amb...

OBJECTIVES The aim of this study was to evaluate the occurrence and dissemination of acquired carbapenem-hydrolysing class D beta-lactamase (class D carbapenemase)- and metallo-beta-lactamase (MBL)-encoding genes among Acinetobacter spp. isolates recovered from medical centres in the Asia-Pacific (APAC) region. METHODS During 2006-07, 41 medical centres located in 10 countries in the APAC reg...

Bacterial sepsis is one of the major causes of morbidity and mortality among neonates. It is characterized as generalized bacterial infection indicated by positive blood culture in the first four weeks of life (Agarwal et al., 2001). The common causative agents for neonatal sepsis are Staphylococcus spp, Enterococci spp, E. coli, Klebsiella spp, Enterobacter spp, Pseudomonas aeruginosa and Acin...

Acinetobacter spp. has emerged as a significant hospital pathogen, quickly becoming resistant to commonly used routine drugs. Colistin remains as the only drug of choice for carbapenem resistant Acinetobacter. In our study among 65 strains of Acinetobacter isolated from different clinical samples, 2 strains showed Colistin resistance by Disk diffusion method .It was confirmed by performing mini...

The genus Acinetobacter comprises 47 characterised genomic species, among which species belonging to the Acinetobacter calcoaceticus–Acinetobacter baumannii complex are the most clinically relevant. Within this complex, A. baumannii, Acinetobacter nosocomialis (formerly genomic species 13TU) and Acinetobacter pittii (formerly genomic species 3) are frequently associated with hospital-acquired i...

Background and Objective: Gram-negative pathogens are considered the common cause of wound infections associated with increased mortality and morbidity rates. Antibiotics combination has been used to overcome this problem. Aims: In this study, we identify Gram-negative pathogens found in wound infections and assess the in-vitro efficacy of a combination of amikacin and imipenem against the resi...

Acinetobacter species have become important pathogens in health care settings and are now responsible for substantial mortality and mortality. The resistance among Acinetobacter spp. has also been continuously rising since 2000. Multidrug-resistance (MDR), is defined as simultaneous resistance to fluoroquinolones, aminoglycoside, and third-generation cephalosporins. Data reviewed from Thailand’...

OBJECTIVE To determine factors associated with colonization by carbapenem-resistant Pseudomonas aeruginosa and multiresistant Acinetobacter spp. METHODS Surveillance cultures were collected from patients admitted to the intensive care unit at admission, on the third day after admission and weekly until discharge. The outcome was colonization by these pathogens. Two interventions were implemen...

Septicaemia remains a significant cause of morbidity and mortality in the newborns in the developing countries. According to National Neonatal Perinatal Database (2000) in India, the incidence of neonatal septicemia is 24/1000 live births. Changing bacterial flora and emergence of resistant strains further aggravate the problem. Acinetobacter spp. have emerged as important nosocomial pathogens....

The present study aimed to evaluate antimicrobial activity of tigecydcline against 84 multidrug resistant (MDR) Acinetobacter spp. strains by disc diffusion and E-test methods. The results of disc diffusion test were compared according to two different interpretation ways. In addition, E-test results and the disc diffusion results that interpreted by both the methods were checked for compatibil...