Omeprazole, a proton-pump inhibitor used in peptic ulcers, gastro-esophageal-reflux disorder, Zollinger-Ellison syndrome and in H. pylori infections. The omeprazole is unstable at acidic pH, undergoes degradation in stomach. To prevent the degradation in stomach, dosage forms are supplied as enteric-coated tablets or granules encapsulated in gelatin capsules. The efficiency of such dosage forms...

The discovery of the pH Low Insertion Peptides (pHLIPs®) provides an opportunity to develop imaging and drug delivery agents targeting extracellular acidity. Extracellular acidity is associated with many pathological states, such as those in cancer, ischemic stroke, neurotrauma, infection, lacerations, and others. The metabolism of cells in injured or diseased tissues often results in the acidi...

Factors associated with soil acidity are considered to be limiting for plants in many parts of the world. This work was undertaken to investigate the role of the toxicity of hydrogen (H(+)) which seems to have been underconsidered by ecologists as an explanation of the reduced plant growth observed in very acid soils. Racial differences are reported in plant growth response to increasing acidit...

desirability and good background of yogurt have led the manufacturers to use this product mostly for producing milk-based probiotic products. the aim of this study was to evalutate the effect of a mixture of prebiotics including oligofructose, lactulose, and inulin on physicochemical properties (ph value, acidity, and syneresis) of synbiotic yogurt containing lactobacillus casei. pasteurized mi...

Radiolabeled phytoplankton and macrophyte lignocelluloses were incubated at pHs 4 and 7 in water from a naturally acidic freshwater wetland (Okefenokee Swamp; ambient pH, 3.8 to 4.2), a freshwater reservoir (L-Lake; pH 6.7 to 7.2), and a marine marsh (Sapelo Island; pH approximately 7.8). The data suggest that acidity is an important factor in explaining the lower decomposition rates of algae i...

The plasma membrane H+-ATPase Pma1 and the vacuolar V-ATPase act in close harmony to tightly control pH homeostasis, which is essential for a vast number of physiological processes. As these main two regulators of pH are responsive to the nutritional status of the cell, it seems evident that pH homeostasis acts in conjunction with nutrient-induced signalling pathways. Indeed, both PKA and the T...

The effects of wood ash fertilization on soil chemical properties were studied in three young Scots pine (Pinus sylvestris L.) plantations and a Norway spruce (Picea abies (L.) Karst.) plantation with different site fertility in southern Finland. The dose of 3 t ha–1 of loose wood ash was applied to 4 replicate plots (25 × 25 m) at each experiment. Humus layer and mineral soil samples were take...

Dental alloys for direct metal laser sintering (DMLS) are available on the market today, but there is little scientific evidence reported on their characteristics. One of them is the release of ions, as an indicator of the corrosion characteristics of a dental alloy. Within this research, the difference in the elution of metals from DMLS and cast (CM) samples of Co-Cr-Mo dental alloy in saliva-...

To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the two pH recordings made in each subject after one week courses of placebo or om...

Gastric infection by Helicobacter pylori is the most common cause of ulcer disease and gastric cancer. The mechanism of progression from gastritis and inflammation to ulcers and cancer in a fraction of those infected is not definitively known. Significant acidity is unique to the gastric environment and is required for ulcer development. The interplay between gastric acidity and H. pylori patho...