Many studies have been done over the years to assess the effectiveness of Echinacea as an immunomodulator. We have assessed the potential bioavailability of alkyl- amides and caffeic acid conjugates using Caco-2 monolayers and compared it to their actual bioavailability in a Phase I clinical trial. The caffeic acid conjugates permeated poorly through the Caco-2 monolayers. Alkylamides were foun...

BACKGROUND Ingestion of low-digestible carbohydrates triggers symptoms in patients with irritable bowel syndrome (IBS). These carbohydrates become substrates for microbial fermentation in the colon, yielding short-chain fatty acids (SCFAs) that are readily absorbed. Aiming to compare colonic fermentation in patients with IBS and healthy controls, we analyzed the concentrations of SCFA in serum ...

we present a case of caustic ingestion by a 1.5-year-old boy. the caustic agent was drain opener which is a strong alkaline substance. children in iran and many other countries are still exposed to not “child proof” (child resistant packaging) toxic substance containers. ingestion of caustic agents may lead to necrosis, perforation, and strictures. substances that are ingested more frequently a...

background the purpose of this study was to evaluate the characteristics, management, and outcomes of disc battery ingestion in children. methods we reviewed the medical records of children admitted to mofid children's hospital due to disc battery ingestion from january 2006 to january 2010. clear history, clinical symptoms and results of imaging studies revealed diagnosis of disc battery inges...

Alpha-lipoic acid has been found to enhance glucose uptake into skeletal muscle in animal models. Studies have also found that the co-ingestion of carbohydrate along with creatine increases muscle creatine uptake by a process related to insulin-stimulated glucose disposal. The purpose of this study was to determine the effect of alpha-lipoic acid on human skeletal muscle creatine uptake by dire...

Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide (GIP) is one of the incretins, which are gastrointestinal hormones released in response to nutrient ingestion and potentiate glucose-stimulated insulin secretion. Single fat ingestion stimulates GIP secretion from enteroendocrine K cells; chronic high-fat diet (HFD) loading enhances GIP secretion and induces obesity in ...

Graham, T. E., V. Sgro, D. Friars, and M. J. Gibala. Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans. Am. J. Physiol. Endocrinol. Metab. 278: E83–E89, 2000.—Monosodium glutamate (MSG) ingestion is known to increase plasma glutamate concentration, and MSG infusion stimulates insulin secretion. We investigated the impact of MSG ingestion on both the plasma and i...

Caustic poisonings are still associated with many fatalities. Studies focusing on the elderly are rare. The purpose of the present study was to compare the clinical outcomes of caustic ingestion injury in elderly and non-elderly adults with regard to gender, intent of exposure, substance ingested, severity of mucosal injury, complications, and mortality. Caustic substance exposures reported to ...

Routine detection of health parameters is desirable to recognize the early onset metabolic diseases (e.g., diabetes mellitus) and personalize their treatment. Promising are non-invasive, affordable portable technologies, such as breath sensors. Yet, selective monitoring markers acetone for lipolysis) with sensors track changes that can reveal disease-related abnormalities remains challenging. H...