Spirulina and lipoic acid has been considered as one of the most effective in ant oxidative stress anti-inflammatory activity.Aspartame (ASP) is mostwidely used (artificial sweeteners)used a variety foods feeds.This study was conducted to evaluate possible protective effect alpha-lipoic against aspartame induced brain damage rabbits. Forty two white male New-Zealand Rabbits were classified into...

Melasma is a localized, chronic acquired hypermelanosis of the skin. Despite several treatments available, melasma can often be refractory to treatment. Also recurrences are common. Tranexamic acid is a new addition in treatment of melasma and is effective in dosage of 250 mg BD for atleast 4 to 8 weeks. Tranexamic acid acts mainly via the plasminogen activator-plasmin system to prevent UV radi...

There is accumulating evidence that omega-3 fatty acids may modulate immune responses. When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or negatively, depending on the markers tested and the maturation stage of the DC...

Plasminogen activator activity has been localized in gastric and duodenal tissue using a histological technique. This activity could be separated from proteolytic activity by incorporating in-aminocaproic acid into the fibrin substrate or by heat treatment. Plasminogen activator activity was found in relation to mucosal and submucosal blood vessels in the tissues studied. Proteolytic activity w...

Meyerhof (1) in 1927 obtained an "activator" from yeast which restored to aged muscle juice its lost ability to ferment glucose. In 1935 yon Euler and Adler (2) found an enzyme in yeast which catalyzed the transfer of phosphorus from adenosine triphosphate to hexoses. They named the enzyme "heterophosphatese." Meyerhof (3) then established that his "activator" of 1927, which he renamed "hexokin...

The transcriptional activator protein Gcn4p increases the transcription of many genes that code for amino acid synthesis genes during amino acid starvation in Saccharomyces cerevisiae. Here we showed that after the disruption of C-GCN4, a homolog in Candida maltosa of GCN4 in S. cerevisiae, formed pseudohyphae in minimal medium. This is the first report that a GCN4 homolog is involved in the co...

High-performance affinity chromatography was performed on five ligand-bound columns in an attempt to purify tissue-type plasminogen activator (t-PA), which is a glycoprotein with a high affinity for fibrin and also has two Kringle structures and finger-domain in its molecule. The five columns were concanavalin A-5PW, p-aminobenzamidine-5PW, imidinodiacetic acid-5PW, boric acid-5PW and lysine-5P...

Escherichia coli OmpT is an outer membranebound endoprotease consisting of 297 amino acid residues.':2) It belongs to the serine peptidase family S18') and the deduced amino acid sequence has high simiIarity to those of the }'ersinia pestis plasminogen activator,4) Satmone"a mphimurium E protein,5} E. coli OmpP,6} and Shigella fllexneri SopA proteins.'} The physiological function of OmpT has be...