The complex and multifactorial nature of neuropsychiatric diseases demands multi-target drugs that can intervene with various sub-pathologies underlying disease progression. Targeting the impairments in cholinergic glutamatergic neurotransmissions small molecules has been suggested as one potential disease-modifying approaches for Alzheimer’s (AD). Tacrine, a potent inhibitor acetylcholinestera...

In this study, the enzyme activity of anthraquinone compounds which were synthesized beforehand by our research group was investigated. Molecular docking studies performed for 1-(4-aminophenylthio)anthracene-9,10-dione (3) and 1-(4-chlorophenylthio)anthracene-9,10-dione (5). Compound 3 from reaction 1-chloroanthraquinone (1) 4-aminothiophenol (2). 5 4-chlorothiophenol (4). Anthraquinone analogs...

The plant, Camellia sinensis (leaves) is popularly known for its usage as tea in many parts of the world, including Nigeria. purpose this study was to screen bioactive compositions and determine endogeneous antioxidant potentials fresh processed (tea) C. aqueous leaf extract. Phytochemicals, minerals vitamins analysis were carried out following standard procedures. extracts further administered...

Pesticides on Human Subjects Concluded “No Effect,” Despite the Evidence The National Academy of Sciences (NAS) convened a panel of scientists in early 2003 to advise the U.S. Environmental Protection Agency (EPA) on the scientific and ethical issues surrounding the use of toxicologic studies conducted by third parties on human subjects (NAS 2003). These studies are generally sponsored by chemi...

This study was designed to investigate the effects of the cholinesterase inhibitors soman and pyridostigmine bromide (PB) on synaptic transmission in the CA1 field of rat hippocampal slices. Soman (1-100 nM, 10-15 min) decreased the amplitude of GABAergic postsynaptic currents (IPSCs) evoked by stimulation of Schaffer collaterals and recorded from CA1 pyramidal neurons. It also decreased the am...

Surgical specimens of normal human extraocular muscle repealed in electron microscopic cross sections two distinct types of extrafusal fibers: (1) a fibrillar type (Fibrillenstniktur) and (2) an essentially afibrillar type (Felderstruktur). Fascicles of autopsy muscle, stained with a modified Koelle technique to demonstrate cholinesterase activity, showed by light microscopy two kinds of nerve ...