نتایج جستجو برای: acetaminophen poisoning

تعداد نتایج: 39034  

2015
Yanli Zhao Jerold S. Harmatz Carol R. Epstein Yukako Nakagawa Chie Kurosaki Tetsuro Nakamura Takumi Kadota Dennis Giesing Michael H. Court David J. Greenblatt

AIMS The antiviral agent favipiravir is likely to be co-prescribed with acetaminophen (paracetamol). The present study evaluated the possiblility of a pharmacokinetic interaction between favipiravir and acetaminophen, in vitro and in vivo. METHODS The effect of favipivir on the transformation of acetaminophen to its glucuronide and sulfate metabolites was studied using a pooled human hepatic ...

Journal: :The Journal of the American Board of Family Practice 1998
G L Maze M Lee

Acetaminophen is a popular over-the-counter analgesic used for headaches and minor musculoskeletal pains. Most persons taking therapeutic doses of acetaminophen experience no side effects. \¥hen taken in greater than the recommended dosage, however, acetaminophen can cause serious complications, including liver and renal failure as well as death. l This outcome is especially evident in those wh...

Journal: :Rhode Island medical journal 2013
Jay H Levin Margaret M Gordon Frederick W Burgess

BACKGROUND Prescription opioid-acetaminophen products account for the majority of cases of acetaminophen-related acute liver failure in the United States. We sought to examine the frequency of opioid-acetaminophen overuse at the Providence VA Medical Center and improve the quality and safety of opioid-acetaminophen prescription practices in a system employing electronic health records and e-pre...

2009
R. Ponampalam Hock Heng Tan Kee Chong Ng Wee Yee Lee Sau Chew Tan

BACKGROUND The demographics of poisoned patients and the circumstances of toxic exposure have not been evaluated in Singapore for the last 10 years. AIM This study aims to give an estimate of the burden of poisoning in Singapore from the emergency department's (ED) perspective. METHOD A retrospective study of toxic exposure was conducted over a period of 3 years from 2001 to 2003 at the ED ...

Journal: :Molecular pharmacology 2005
Jun Gu Huadong Cui Melissa Behr Li Zhang Qing-Yu Zhang Weizhu Yang Jack A Hinson Xinxin Ding

Acetaminophen overdose causes toxicity in liver and extrahepatic tissues. Although it is well established that cytochrome P450 enzymes play a critical role in the metabolic activation of acetaminophen, it is not yet clear whether acetaminophen toxicity in extrahepatic tissues is a consequence of hepatic biotransformation. The aim of this study was to determine whether extrahepatic acetaminophen...

2016
Sammy Saab Peter G. Konyn Matthew R. Viramontes Melissa A. Jimenez Jonathan F. Grotts Wally Hamidzadah Veronica P. Dang Negin L. Esmailzadeh Gina Choi Francisco A. Durazo Mohamed M. El-Kabany Steven-Huy B. Han Myron J. Tong

Background and Aims: Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United States. Patients with underlying liver disease are at higher risk of poor outcomes from acetaminophen overdose. Limited knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver failure. The purpose of this study is to asse...

2017
Ryan G Thomas Brenda M Rivera Reyes Benjamin M Gaston Nelki B Rivera Acosta Ilya R Bederman Laura A Smith Morgan T Sutton Benlian Wang John F Hunt Tracey L Bonfield

BACKGROUND An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic pathology. In acidic conditions like those in the stomach and inflamed airway, tyrosine residues are nitrated by nitrous and peroxynitrous acids. The...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2003
Janet Dowdy Stacey Brower Michael R Miller

The purpose of this study was to test the hypothesis that acetaminophen would alter an estrogen-regulated process in human cells that express endogenous estrogen receptor alpha and beta (ERalpha and ERbeta). Specifically, the extent to which acetaminophen altered the expression of estrogen-inducible alkaline phosphatase in endometrial adenocarcinoma (Ishikawa) cells and directly interacted with...

2015
Attalla Farag El-Kott Mashael Mohammed Bin-Meferij

BACKGROUND Severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure. OBJECTIVE To investigate the ameliorative effects of Arctium lappa root extract on acetaminophen-induced hepatotoxicity. METHODS Rats were divided into 4 groups: normal control group, Arctium lappa extract group, acetaminophen-injected group, and acetaminophen treat...

2017
Alyssa Gallipani A Scott Mathis Hoytin Lee Ghin Germin Fahim

BACKGROUND The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking. OBJECTIVE To determine whether there is a difference in frequency and type of adverse effects between intravenous acetaminophen-treated and non-intravenous acetaminophen-treated pat...

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