نتایج جستجو برای: abcc1
تعداد نتایج: 519 فیلتر نتایج به سال:
The reported prevalence of occult carcinomas of the thyroid gland varies considerably. The thyroid glands in unselected autopsies revealed 24% occult carcinomas in the Japanese living in Hawaii (Fukunaga and Lockett 1971) and 17.9% of native Japanese in the Atomic Bomb Casualty Commission (ABCC) study in Hiroshima and Nagasaki, Japan (Sampson et al. 1969). American reports, however, revealed on...
M ANY hematologic studies have been made on the survivors of the atomic bombs dropped on Hiroshima and Nagasaki, hut since few have dealt with the children irradiated in utero,14 we have investigated the general hematologic findings in these children. A group of children exposed to the Hiroshima A-Bomb while in utero and a nonexposed group have been examined yearly at the Atomic Bomb Casualty C...
The Atomic Bomb Casualty Commission (ABCC) is an epidemiological research institute in Hiroshima and Nagasaki, cooperatively sponsored by the United States National Academy of Sciences and the Japanese National Institutes of Health of the Japanese Ministry of Health and Welfare to investigate the sequelae of radiation upon man. One phase of the comprehensive program,' designed to study the late...
For 50 years, the Atomic Bomb Casualty Commission (ABCC) and its successor, the Radiation Effects Research Foundation (RERF), have conducted epidemiological and genetic studies of the survivors of the atomic bombs and of their children. This research program has provided the primary basis for radiation health standards. Both ABCC (1947-1975) and RERF (1975 to date) have been a joint enterprise ...
Sildenafil is a potent and selective inhibitor of the type 5 cGMP (cyclic guanosine 3',5'-monophosphate)-specific phosphodiesterase that is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. Here, we report that sildenafil has differential effects on cell surface ABC transporters such as ABCB1, ABCC1, and ABCG2 that modulate intracompartmental and intracellular c...
BACKGROUND The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding cassette (ABC) transporters actively transport various xenobiotics across biological membranes. OBJECTIVE To investigate the role of ABC polymorphisms as modifiers of prenatal exposure to MeHg. METHODS The study population consisted of participants (n = 1651) in two birth cohorts, ...
Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore analyzed the expression and localization of six members of the multidrug resist...
Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer cells (H460) enriched for stem cell growth in a defined serum-free med...
Delivery of therapeutic agents to the brain and its neoplasms depends on the presence of membrane transport proteins in the blood-brain barrier and in the target cells. The cellular and subcellular localization of these membrane transporters determines the drug accessibility to the brain and its tumors. We therefore analyzed the expression and localization of six members of the multidrug resist...
ATP-binding cassette (ABC) transporters together with phase I and II detoxification enzymes have been considered as included in a cellular detoxification system. Previous studies have highlighted the involvement of aryl hydrocarbon receptor (AHR) and Cyp1a in PAH-induced embryo toxicity. However, the response of other xenobiotic enzymes/transporters in PAH-mediated embryo toxicity is not fully ...
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