نتایج جستجو برای: aat

تعداد نتایج: 1220  

Journal: :Plant physiology 1992
F J Turano J M Weisemann B F Matthews

A full-length cDNA clone encoding aspartate aminotransferase (AAT) has been identified from a carrot root cDNA library. Degenerate oligo primers were synthesized from the known amino acid sequence of AAT form I from carrot (Daucus carota L. cv Danvers). These primers were utilized in a polymerase chain reaction to amplify a portion of a carrot AAT gene from first strand cDNA synthesized from po...

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2004
Adrienne S. Ettinger

Background: Individuals with severe Z α1-antitrypsin (AAT) deficiency have a considerably increased risk of developing chronic obstructive lung disease (COPD). It has been hypothesized that compensatory increases in levels of other protease inhibitors mitigate the effects of this AAT deficiency. We analysed plasma levels of AAT, α1-antichymotrypsin (ACT) and secretory leukocyte protease inhibit...

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Journal: :Cancer research 2004
Wei Li Alexei Y Savinov Dmitri V Rozanov Vladislav S Golubkov Hirad Hedayat Tatiana I Postnova Natalia V Golubkova Yu Linli Stanislaw Krajewski Alex Y Strongin

Proteases exert control over cell behavior and affect many biological processes by making proteolytic modification of regulatory proteins. The purpose of this paper is to describe novel, important functions of matrix metalloproteinase (MMP)-26. alpha1-Antitrypsin (AAT) is a serpin, the primary function of which is to regulate the activity of neutrophil/leukocyte elastase. Insufficient antiprote...

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Journal: :Immunology letters 2006
Radinka Hadzic Izabela Nita Helena Tassidis Kristian Riesbeck Anette Gjörloff Wingren Sabina Janciauskiene

Alpha1-antitrypsin (AAT) is a major circulating and tissues inhibitor of serine proteinases implicated in the regulation of inflammation and host defence. There is now increasing evidence that AAT may also exhibit anti-inflammatory activities independent of its protease inhibitor function. This study was undertaken to investigate the effects of native (inhibitory) and polymerized (non-inhibitor...

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Journal: :The journal of ECT 2003
Sandra B Barker Anand K Pandurangi Al M Best

OBJECTIVE To determine whether animal-assisted therapy (AAT) is associated with reductions in fear, anxiety, and depression in psychiatric patients before electroconvulsive therapy (ECT). MATERIALS AND METHODS Before their scheduled ECT treatment, 35 patients were assigned on alternate days to the treatment condition, consisting of a 15-minute AAT session, and the standard (comparison) condit...

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Journal: :The Journal of clinical investigation 2013
Christian Mueller Jeffrey D Chulay Bruce C Trapnell Margaret Humphries Brenna Carey Robert A Sandhaus Noel G McElvaney Louis Messina Qiushi Tang Farshid N Rouhani Martha Campbell-Thompson Ann Dongtao Fu Anthony Yachnis David R Knop Guo-Jie Ye Mark Brantly Roberto Calcedo Suryanarayan Somanathan Lee P Richman Robert H Vonderheide Maigan A Hulme Todd M Brusko James M Wilson Terence R Flotte

Recombinant adeno-associated virus (rAAV) vectors have shown promise for the treatment of several diseases; however, immune-mediated elimination of transduced cells has been suggested to limit and account for a loss of efficacy. To determine whether rAAV vector expression can persist long term, we administered rAAV vectors expressing normal, M-type α-1 antitrypsin (M-AAT) to AAT-deficient subje...

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2014
A. Mario Marcondes Ekapun Karoopongse Marina Lesnikova Daciana Margineantu Tobias Welte Charles A. Dinarello David Hockenbery Sabina Janciauskiene Joachim Deeg

Allogeneic hematopoietic stem cell transplantation is curative in many patients with leukemia and other lymphohematopoietic disorders. However, the immune response of donor cells that mediate the graft-versus-leukemia (GVL) effect, leading to disease eradication, also triggers graft-versus-host disease (GVHD). Preventing GVHDwhile maintaining the GVL effect would be a major advance. Several rec...

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Journal: :Respiratory Research 2005
Izabela Nita Camilla Hollander Ulla Westin Sabina-Marija Janciauskiene

BACKGROUND Alpha1-antitrypsin (AAT) serves primarily as an inhibitor of the elastin degrading proteases, neutrophil elastase and proteinase 3. There is ample clinical evidence that inherited severe AAT deficiency predisposes to chronic obstructive pulmonary disease. Augmentation therapy for AAT deficiency has been available for many years, but to date no sufficient data exist to demonstrate its...

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2006
JUN AMANO

We report herein a case of hyperthyroid Graves' disease developed from asymptomatic autoimmune thyroiditis (AAT). A 25-year-old single female with AAT was followed up for over 3 years. Thereafter her condition progressed to hyperthyroidism with both positive TSH receptor antibodies (TRAb) and an increase in antithyroidal antibodies. It is possible that there was continuous destruction of thyroi...

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2016
Doris R. Medina-Garin Aissata Dia Gabriel Bedubourg Xavier Deparis Franck Berger Remy Michel

CONTEXT Despite existing preventive measures, the number of acute acoustic trauma (AAT) cases reported to the French Military Epidemiological Surveillance System (MESS) remains high. AIMS The objective of this study was to describe AAT and the preventive measures already implemented. SUBJECTS AND METHODS We conducted a descriptive cross-sectional analysis of AAT using data from the MESS for...

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