نتایج جستجو برای: aaa

تعداد نتایج: 5367  

Journal: :BMC Cardiovascular Disorders 2008
Lars Ehlers Jan Sørensen Lotte Groth Jensen Merete Bech Mette Kjølby

BACKGROUND Ruptured abdominal aortic aneurysm (AAA) is responsible for 1-2% of all male deaths over the age of 65 years. Early detection of AAA and elective surgery can reduce the mortality risk associated with AAA. However, many patients will not be diagnosed with AAA and have therefore an increased death risk due to the untreated AAA. It has been suggested that population screening for AAA in...

2015
Evan J. Ryer Kaitryn E. Ronning Robert Erdman Charles M. Schworer James R. Elmore Thomas C. Peeler Christopher D. Nevius John H. Lillvis Robert P. Garvin David P. Franklin Helena Kuivaniemi Gerard Tromp Jonathan Golledge Joseph V. Moxon

Abdominal aortic aneurysm (AAA) is a complex disorder that has a significant impact on the aging population. While both genetic and environmental risk factors have been implicated in AAA formation, the precise genetic markers involved and the factors influencing their expression remain an area of ongoing investigation. DNA methylation has been previously used to study gene silencing in other in...

2016
Hirona Kugo Nobuhiro Zaima Hiroki Tanaka Youhei Mouri Kenichi Yanagimoto Kohsuke Hayamizu Keisuke Hashimoto Takeshi Sasaki Masaki Sano Tatsuro Yata Tetsumei Urano Mitsutoshi Setou Naoki Unno Tatsuya Moriyama

Abdominal aortic aneurysm (AAA) is a vascular disease involving the gradual dilation of the abdominal aorta. It has been reported that development of AAA is associated with inflammation of the vascular wall; however, the mechanism of AAA rupture is not fully understood. In this study, we investigated the mechanism underlying AAA rupture using a hypoperfusion-induced animal model. We found that ...

2014
Jonathan Golledge Graeme J. Hankey Bu B. Yeap Osvaldo P. Almeida Leon Flicker Paul E. Norman

BACKGROUND Salt intake has been implicated in the pathogenesis of abdominal aortic aneurysm (AAA) through studies in rodent models but not previously studied in humans. The aim of this study was to examine the association between reported addition of salt to food and the prevalence of AAA. METHODS A risk factor questionnaire which contained a question about salt intake was included as part of...

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2013
Irene Hinterseher Robert Erdman James R Elmore Elizabeth Stahl Matthew C Pahl Kimberly Derr Alicia Golden John H Lillvis Matthew C Cindric Kathryn Jackson William D Bowen Charles M Schworer Michael A Chernousov David P Franklin John L Gray Robert P Garvin Zoran Gatalica David J Carey Gerard Tromp Helena Kuivaniemi

OBJECTIVES Abdominal aortic aneurysm (AAA), a dilatation of the infrarenal aorta, typically affects males >65 years. The pathobiological mechanisms of human AAA are poorly understood. The goal of this study was to identify novel pathways involved in the development of AAAs. METHODS A custom-designed 'AAA-chip' was used to assay 43 of the differentially expressed genes identified in a previous...

Journal: :Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 2004
Keisuke Morimoto Iwao Taniguchi Shigeto Miyasaka Tetsuya Aoki Ippei Kato Takeshi Yamaga

Abdominal aortic aneurysm (AAA) is commonly associated with coronary artery disease (CAD). Simultaneous coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) under cardiac arrest and AAA repair may be considerably invasive. Recently CABG under the beating heart without CPB has been reported as a less invasive method. We report the combined operation of CABG on a beating heart...

2013
Suresh Rana Kevin Rogers Shyam Pokharel Terry Daniel Reed Christopher Biggs

Our purpose in this study was to assess the dosimetric impact of the Acuros XB algorithm (AXB), in comparison with Anisotropic Analytical Algorithm (AAA) calculations, for esophageal cancer treatment plans created with RapidArc technique. First, we performed a phantom study by comparing the percent depth dose (PDD) calculated by AXB and AAA against the measured PDD in a slab phantom containing ...

Journal: :Vascular Health and Risk Management 2006
Martin Claridge Simon Hobbs Clive Quick Donald Adam Andrew Bradbury Teun Wilmink

INTRODUCTION Several studies have found an increased incidence of peripheral aneurysms in patients with an abdominal aortic aneurysm (AAA). The aim of this study was to determine whether screening for popliteal aneurysms should be part of an AAA screening programme. SETTING A community-based AAA screening programme. METHODS The diameters of the internal abdominal aorta and both popliteal ar...

Journal: :Hypertension 2006
Suguru Shiraya Ken Miwa Motokuni Aoki Takashi Miyake Masako Oishi Kazusaburo Kataoka Shigetsugu Ohgi Toshio Ogihara Yasufumi Kaneda Ryuichi Morishita

In this study, we focused on the effect of hypertension on the transcription factors nuclear factor kappaB (NFkappaB) and ets in the mechanisms of abdominal aortic aneurysm (AAA), and we investigated how hypertension affects the progression of AAA. AAA was produced by elastase perfusion in hypertensive rats and normotensive rats. The size of AAA rapidly increased in hypertensive rats as compare...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2011
Jiusong Sun Galina K Sukhova Jie Zhang Han Chen Sara Sjöberg Peter Libby Meixiang Xiang Jianan Wang Christoph Peters Thomas Reinheckel Guo-Ping Shi

OBJECTIVE The development of abdominal aortic aneurysms (AAA) requires extensive aortic wall matrix degradation. Human AAA lesions express high levels of cathepsin L (CatL), one of the most potent mammalian elastases. Whether this protease participates directly in AAA pathogenesis, however, is unknown. METHODS AND RESULTS We generated experimental AAA with aortic elastase perfusion in mice an...

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