Background: A patient with multiple myeloma developed myelodysplastic syndrome (MDS). Chromosomal analysis performed after the development of MDS revealed monosomy of chromosome 9 in all the meta-phases. We wished to identify the extent of the clone with the chromosomal abnormality originating from MDS clone. Methods: A correlative interphase study by fluorescence in situ hybridization (FISH) w...

background: interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (ms). the most frequent systemic adverse effects are flu-like symptoms. laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. myelodysplastic syndrome (mds) refers to a spectrum of hematological disorders which can occur in different situations. sever...

In this article, a novel acceptance-sampling plan is proposed to decide whether to accept or reject a receiving batch of items. In this plan, the items in the receiving batch are inspected until a nonconforming item is found. When the sum of two consecutive values of the number of conforming items between two successive nonconforming items falls underneath of a lower control threshold, the batc...

Extended Abstract. Let Xi1 ,..., Xini   ,i=1,2,3,....,k  be independent random samples from distribution $F^{alpha_i}$،  i=1,...,k, where F is an absolutely continuous distribution function and $alpha_i>0$ Also, suppose that these samples are independent. Let Mi,ni and  M'i,ni  respectively, denote the maximum and minimum of the ith sa...

Patients with myelodysplastic syndrome (MDS) have ineffective in vivo and in vitro erythropoiesis, characterized by an impaired response to erythropoietin (Epo). We examined proliferation and maturation of MDS marrow cells in response to Epo in more detail. Epo-dependent DNA synthesis as well as induction of GATA-1 binding activity in marrow cells from 15 MDS cases were severely reduced as comp...

Multi-access Edge Computing (MEC) has recently emerged as a potential technology to serve the needs of mobile devices (MDs) in 5G and 6G cellular networks. By offloading tasks high-performance servers installed at edge wireless networks, resource-limited MDs can cope with proliferation recent computationally-intensive applications. In this paper, we study computation problem massive multiple-in...

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic disorders characterized by ineffective hematopoiesis, bone marrow dysplasia, and peripheral cytopenias. Familial forms of MDS have traditionally been considered rare, especially in adults; however, the increasing availability of somatic and germline genetic analyses has identified multiple susceptibility loci. Bone marrow fa...

This paper proposes a framework that enhances domain independent heuristic state-space planners with the ability to plan for multiple criteria simultaneously. A criteria hierarchy, together with preferences among them and boundaries over their values, is defined by the knowledge engineer. For the search process in the state-space, a weighted A* strategy is adopted. The heuristic function uses t...

Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit te...

The association of Myelodysplasia (MDS) and multiple myeloma (MM) has been usually described not only as a complication of chemotherapy but also in the absence of preceding chemotherapy or together at the time of diagnosis. Optimal therapies of a coexisting MM and MDS have not been well established up to now. We report a case of MDS diagnosed simultaneously with MM. After treatment with VTD (bo...