Crocin, the main constituent of saffron (Crocus sativus L.), is a natural carotenoid which is known for its antioxidant activity. Liver as the organ that metabolizes many chemicals is one of the first position that is at risk of environmental pollutants. It is clear that compounds that exhibit antioxidant properties, scavenging of free radicals and inhibition of lipid peroxidation are expected ...

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

objective: oxidative stress damages cells and brings about the pathogenesis of ischemia/reperfusion injury. this study was carried out to investigate the preconditioning and cardio protective potential effects of crocin and vitamin e by the enos and inos express gene in ischemia/reperfusion in rats. material & methods: male rats were divided into seven groups, namely: sham, control group and ex...

objective(s): in this study, the effects of crocin against subchronic toxicity of diazinon (dzn) on systolic blood pressure (sbp) and heart rate (hr) were evaluated in rats. materials and methods: rats were equally divided into 7 groups; control (corn oil), dzn (15 mg/kg), crocin (each group received 12.5, 25 or 50 mg/kg crocin plus dzn), vitamin e (200 iu/kg plus dzn) and crocin (50 mg/kg) tre...

objective: crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. the present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. materials and methods: local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...

Objective(s):Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. One of the hallmarks of AD is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. In this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in AD and tauopathies. Unfortunately, the available syntheti...

Introduction: It has been reported that doxorubicin can cause liver damage; however, exercise and crocin consumption can improve antioxidant defense.The aim of the present study was to investigate the antioxidant effect of continuous training with crocin consumption on the liver tissue of doxorubicin-poisoned rats. Methods: In this experimental...

Introduction: In this study, two constituents of saffron stigma (crocin and safranal) were tested for possible cytotoxic and antitumoral activity using brine shrimp and potato disc assays. Methods: In the brine shrimp assay, three wells containing 10 nauplii were tested for each concentration. After 24h, the number of the nauplii was counted. To investigate the antimicrobial activity of safr...

Background: The application of methotrexate (MTX) as a chemotherapy agent and immune system suppressant has various side effects. Crocin, a xanthine derivative plant, has many therapeutic benefits. This study was planned to assess the effect of crocin on renal toxicity of MTX in a rat model. Methods: Forty eight rats were divided randomly into eight groups (n = 6), which received normal saline,...

objectives: crocin and safranal, the major constituents of saffron, exert neuroprotective effects. in the present study, we investigated the effects of crocin and safranal  (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. materials and methods: diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (stz) and confirmed by blood glu...