This study aimed to prepare a novel radiopharmaceutical for the detection of brain disorders at early stages in susceptible patients.Promazine hydrochloride was labeled with 125I by direct electrophilic substitution reaction high labeling yields 92.6 ± 3.24 %. The yield and vitro stability 125I-promazine were determined paper electrophoresis, chromatography (PC) High performance liquid (HPLC). ...

BACKGROUND Patients with hypertrophic cardiomyopathy (HCM) sometimes develop subendocardial ischemia (SEI) in the left ventricle (LV). In the present study it was examined whether volumetric variables obtained by gated single-photon emission computed tomography (SPECT) are useful in detecting exercise-induced SEI in patients with HCM. METHODS AND RESULTS Exercise 99mTc-tetrofosmin myocardial ...

BACKGROUND We define the repeatability coefficients (RC) of key quantitative and visual perfusion and function parameters that can be derived by the QGS/QPS automated software and by expert visual observer from gated myocardial perfusion SPECT (MPS) scans. METHODS Standard QGS/QPS algorithms have been applied to derive quantitative perfusion and function parameters in 200 99mTc-tetrofosmin re...

Nuclear cardiology uses radioisotopes to study various aspects of cardiac pathophysiology. Using the techniques of SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) one can study myocardial function, perfusion, metabolism, receptors, infarction, atherosclerosis, apoptosis and success of gene therapy. Gated Blood Pool (GBP / MUGA) studies provide an accura...

BACKGROUND Images of myocardial perfusion taken during an episode of chest pain have been used for patients in the emergency department. OBJECTIVE To evaluate the operating characteristics of 99mTc-Tetrofosmin scintigraphy during an episode of chest pain to exclude the diagnosis of acute myocardial infarction. METHODS One hundred and eight patients admitted with chest pain, or up to four ho...

xercise or pharmacological stress myocardial perfusion single-photon emission computed tomography (SPECT) has been used in daily clinical practice as a reliable diagnostic modality and a prognostic marker for patients with coronary artery disease.1–3 We herein report atypical exercise stress myocardial perfusion SPECT imaging in a patient with effort angina pectoris. A 58-year-old male who had ...

BACKGROUND Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. METHO...

INTRODUCTION AND OBJECTIVES Systolic function and myocardial perfusion are evaluated before hospital discharge and can change during follow-up. The purpose of this study was to evaluate these parameters by gated-SPECT in the first year after acute myocardial infarction. PATIENTS AND METHOD We studied 74 consecutive patients with a first uncomplicated acute myocardial infarction (49 infero-lat...

INTRODUCTION L,L-ethylenedicysteine (EC) is a new carrier of technetium Tc 99m (99mTc) with a lower affinity to plasma albumin in comparison with diethylenetriamine pentaacetic acid (DTPA). We compared 99mTc-EC scan with 99mTc-DTPA scan in diuretic renography for patients with obstructive uropathy. MATERIALS AND METHODS Thirty-three patients with upper urinary tract obstruction were randomly ...