in this study the location routing problem with fuzzy parameters is taken into account, this problem involves determining the location of the depots and routing of the vehicles in order to serve the customers. in this study a location routing problem with fuzzy travel times and due dates is considered and two objective models are proposed. the considered objectives are minimizing the total cost...

BACKGROUND The increased prevalence of type 2 diabetes mellitus is a major concern for health providers. We therefore assessed whether voglibose, an alpha-glucosidase inhibitor, could prevent the development of type 2 diabetes in high-risk Japanese individuals with impaired glucose tolerance. METHODS 1780 eligible patients on a standard diet and taking regular exercise with impaired glucose t...

Attachment of polyethylene glycol (PEG) can prolong blood circulation of biological molecules, a useful trait for a vascular imaging agent. Here, we present a route for modifying octabutoxy naphthalocyanine (ONc) with PEG, via axial conjugation following ONc chelation with Sn(IV) chloride (Sn-ONc). Tin chelation caused ONc absorbance to shift from 860 to 930 nm. Hydroxy terminated PEG was treat...

Vehicle routing algorithms usually reformulate the road network into a complete graph in which each arc represents shortest path between two locations. Studies on time-dependent followed this model and therefore defined speed functions graph. We argue that is often inadequate, particular for problems involving services edges of network. To fill gap, we formally define capacitated problem (TDCAR...

We study the strategic interaction among vehicles in a non-cooperative platoon coordination game. Vehicles have predefined routes transportation network with set of hubs where can wait for other to form platoons. decide on their waiting times at and utility function each vehicle includes both benefit from platooning cost waiting. show that game is potential when travel are either deterministic ...