A novel one step regioand stereoselective synthesis of functionalised bicyclo[2.2.2]octenones from readily available aromatic precursors is described. The methodology involved in situ generation of reactive spiroepoxycyclohexadienones and p4sþp2s cycloaddition with methyl vinyl ketone. Study on p-facial alkylation that led to the formation of homobrendane derivatives as a result of stereochemic...

The title compound, C(15)H(16)N(2)O(4), was synthesized from a mixture of α-himachalene (2-methyl-ene-6,6,9-trimethyl-bicyclo-[5.4.O(1,7)]undec-8-ene) and β-himachalene (2,6,6,9-tetra-methyl-bicyclo-[5.4.0(1,7)]undeca-1,8-diene) which were isolated from an oil of the Atlas cedar (Cedrus atlantica). The asymmetric unit contains two independent mol-ecules. In each of the two mol-ecules, two O ato...

Novel bicyclo[3.3.1]nonane derivatives were synthesized by an efficient methodology from acetoacetanilide, 2-methoxy and 4-methoxyacetoacetanilides, 1,3,5-trinitrobenzene and triethylamine. The structures of the compounds were characterized by UV/Visible, FTIR, (1)H NMR and 2D-correlation spectroscopy analysis. The in vitro cytotoxic studies were performed using Ehrlich Ascites Carcinoma cell l...

Reactions of benzoyl pyridine, o-phenylenediamine and anhydrous ZnX2 in methanol afford imine complexes [Zn(L1)X2] (X = Cl, 1; X = Br, 2) in good yields (L1 = (E)-N(1)-(phenyl(pyridin-2-yl)methylene)benzene-1,2-diamine). The reduction of 1 with NaBH4 affords (E)-N(1)-(phenyl(pyridine-2-yl)methylene)benzene-1,2-diamine (L2H). The reaction of L2H with [Ru(II)(PPh3)3Cl2] results in the oxidative d...

In the title compound, C(38)H(29)N(7)O(12), the five-membered ring adopts an envelope conformation in which the 'flap' is cis to the cyclo-propane group. This conformation is similar to those of other bicyclo-[3.1.0]hexane analogues for which crystal structures have been reported. The absolute configuration of the stereogenic centers on the cyclo-pentane ring, as determined by comparison with t...

Preliminary studies of a synthetic approach to the alkaloid stemofoline 1 are reported. Stereoselective cyclisation of the ketoester 14 gave the 1-butyl-2,8-bis(methoxycarbonyl)-8-azabicyclo[3.2.1]octane 21 in which the 2-methoxycarbonyl group is in the axial position. The analogous ketones 15, 18, and 19 were also cyclised to give the 8-azabicyclo[3.2.1]octanes 22-24 with axial electron-withdr...