4-Benzyl-1,2,4-triazin-3,5(2H,4H)-dione (3-benzyl-6-azauracil, 2), and 2,4-dibenzyl-1,2,4-triazin-3,5(2H,4H)-dione (1,3-dibenzyl-6-azauracil, 3) were synthesized by the reaction of 1,2,4-triazin-3,5(2H,4H)-dione (6-azauracil, 1) with benzyl bromide and potassium carbonate in dry acetone via the 18-crown-6-ether catalysis. In these reaction methods, we developed more convenient and efficient met...

The mol-ecule of the title compound, C(18)H(12)N(2)O(4), is situated on a crystallographic centre of symmetry. The mol-ecule has a zigzag structure, with two parallel symmetry-related indoline-2,3-dione fragments linked by an ethyl-ene group at each N atom. In the crystal, the mol-ecules stack in columns along the b axis. There are two such columns in the structure. The mol-ecules within each c...

and/or antioxidant secondary metabolites, for example, carneic acids A—B, cohaerins C—F, daldinins C—F, ramulosin, and sassafrins A—D. During our ongoing search for biologically active metabolites from the endophytic fungi, the broth extract of the xylariaceous fungus PSU-A80, isolated from the leaves of Garcinia atroviridis, showed the antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPP...

A series of 1-cyclopropyl-8-methoxy-quinazoline-2,4-diones was synthesized and evaluated for lowering the ratio of the antimicrobial MIC in gyrase resistance mutants to that in the gyr(+) (wild type) using isogenic strains of Escherichia coli. Dione features that lowered this ratio were a 3-amino group and C-7 ring structure (3-aminomethyl pyrrolidinyl < 3-aminopyrrolidinyl < diazobicyclo < 2-e...

The synthesis of C2-symmetrical bis(β-enamino-pyran-2,4-dione) derivative 3 connected via 1,6-hexylene linker was reported for the first time. X-ray structures and Hirshfeld studies new bis- β-enamino-pyran-2,4-dione along with two structurally related pyran-2,4-dione derivatives 2a,b were discussed. A comparative analysis different intermolecular contacts affecting crystal stability presented....

The proliferation of malware in recent years has motivated the need for tools to detect, analyze, and understand intrusions. Though analysis and detection can be difficult, malware fortunately leaves artifacts of its presence on disk. In this paper, we present Dione, a flexible policy-based disk I/O monitoring and analysis infrastructure that can be used to analyze and understand malware behavi...

In the title compound, C(16)H(12)ClNO(3), an arm-like 4-meth-oxy-benzene links to 5-chloro-indoline-2,3-dione through a methyl-ene group, with a dihedral angle between the mean planes of the benzene ring and the indole moiety of 88.44 (8)°. In the crystal, weak inter-molecular C-H⋯O and π-π stacking inter-actions [centroid-centroid distance = 3.383 (3) Å] link the mol-ecules together to form a ...

The objective of this study was to synthesize several new pregnane derivatives and evaluate them as antiandrogens. From the commercially available 16-dehydropregnenolone acetate (7), two new steroidal compounds were synthesized: 17alpha-hydroxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20-dione (18) and 17alpha-acetoxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20...

The one-pot synthesis of three dragmacidin derivatives is reported. Sarcosine anhydride (4) is brominated and immediately reacted with the corresponding indole to produce the products, namely 3,6-bis(5'-methoxy-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (1), 3,6-bis(7'-methyl-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (2) and 3,6-bis-(6'-chloro-3'-indolyl)-1,4-dimethylpiperazine-2,5-dione (...

Three new abietane-type diterpenoids, 7a-butoxyabieta-8,12-diene-11,14-dione (1), 6a,7a-dihydroxyabieta-8,12-dien-11,14-dione (2), and 6a,7b-dihydroxyabieta8,12-diene-11,14-dione (3) were isolated from the bark of Cryptomeria japonica D. Don. Their structures were established by means of 1D and 2D NMR, IR, UV, and HR-EI-MS spectra and comparison with the data of known analogues. ã 2016 Publishe...