The 48-basepair (48-bp) variable number tandem repeat (VNTR) polymorphism in exon 3 of the dopamine receptor D4 gene (DRD4) is implicated in the etiology of attention-deficit/ hyperactivity disorder (ADHD). In particular, ADHD in European-ancestry population is associated with an increased prevalence of the 7-repeat (7R) allele of the exon 3 VNTR. However, it is intriguing to note that the 7R a...

* IL-7 and IL-15 play important roles in ␥␦ T cell development. These receptors transmit proliferation and/or survival signals in ␥␦ T cells. In addition, the IL-7R promotes recombination and transcription in the TCR ␥ locus. To clarify the role of the cytokine receptors in the development of epidermal ␥␦ T cells, we introduced a V␥3/V␦1 TCR transgene, derived from Thy-1 ؉ dendritic epidermal T...

The protective effect of DNA vaccines expressing the Arg-gingipain A domain against bone loss induced by Porphyromonas gingivalis infection was investigated in a murine model. phgp44, which expresses the 44-kDa adhesion/hemagglutinin domain of Arg-gingipain A, prevented P. gingivalis-induced alveolar bone loss. The results indicate that phgp44 could be a candidate antigen for a vaccine against ...

The powdered roots of the medicinal plant Acacia nilotica were extracted with hexane and ethyl acetate, extracts subjected to column chromatography for isolation potentially bioactive compounds their screening against kinetoplastid pathogens. NMR HREI mass spectrometric analyses identified two new diterpenes, characterized as 16, 19-dihydroxycassa-12-en-15-one (Sandynone, 1 ) (5S, 7R, 8R, 9R, 1...

Let with 0 < 6"', < ~ 2 n) <. .. < 6'n" < 7r. Put cj,, (x) _ II(x-x á). 1 Suppose 0 <_ A < B < 7r. 'e denote by N"(A, B) the number of the z9j in (A, B). Let-1 <-a < b <_ 1. Then we denote by M,,,(a, b) the number of the x i in (a, b). It does not matter whether the intervals (A, B) and (a, b) are open or closed. In a previous paper2Turán and the author proved that if wn(x) be a triangular matr...

A new neolignan glycoside, (7R,8R)-7,8-dihydro-9'-hydroxyl-3'-methoxyl- 8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1'-benzofuranpropanol 9'-O-beta-D- glucopyranoside (1) was isolated from the leaves of Acer truncatum along with (7R,8R)-7,8-dihydro-9'-hydroxyl-3'-methoxyl-8-hydroxymethyl-7-(4-O-alpha-L-rhamno- pyranosyloxy-3-methoxyphenyl)-1'-benzofuranpropanol (2), schizandriside (3), lyonir...

In this paper, we report the anisochrony of the fluorine atoms of a CHF₂ group when linked to a pyrazole ring. The pyrazole is part of (4S,7R)-7,8,8-trimethyl-4,5,6,7-tetrahydro-4,7-methano-2H-indazole also known as (4S,7R)-campho[2,3-c]pyrazole, which has two stereogenic centers. Gauge-Independent Atomic Orbital (GIAO)/Becke, 3-parameter, Lee-Yang-Parr (B3LYP)/6-311++G(d,f) calculated 19F chem...

holds. He was thus led to conjecture the existence of some other partition statistic (which he called the crank); this unknown statistic should provide a combinatorial interpretation of ^-p(lln + 6) in the same way that (1.1) and (1.2) treat the primes 5 and 7. In [4, 5], one of us was able to find a crank relative to vector partitions as follows: For a partition 7r, let #(7r) be the number of ...

T D4 dopamine receptor (DRD4) locus may be a model system for understanding the relationship between genetic variation and human cultural diversity. It has been the subject of intense interest in psychiatry, because bearers of one variant are at increased risk for attention deficit hyperactivity disorder (ADHD) (1). A survey of world frequencies of DRD4 alleles has shown striking differences am...

Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation. Thus, we investigated the mechanism by which IL-7 induced osteoclast formation through IL-7 receptor α (IL-7Rα) in osteoclast precursors. We cultured peripheral blood mononuclear cel...