The role of autophagy, neuroprotective mechanisms of nicotinamide adenine dinucleotide (NAD+), and their relationship in spinal cord ischemic reperfusion injury (SCIR) was assessed. Forty-eight Sprague-Dawley rats were divided into four groups: sham, ischemia reperfusion (I/R), 10 mg/kg NAD+, and 75 mg/kg NAD+. Western blotting, immunofluorescence, and immunohistochemistry were used to assess a...

Investing in research and development spending (R&D) affects total factor productivity (TFP).Recently new theories of economic growth have emphasized the relationship between R&D and TFPand also identified a number of channels through which a country’s R&D affects TFP of its tradepartner. This study seeks to estimate the effect of agricultural R&D and education spending and someother factors on...

We have studied the effects of the H3-receptor agonist (R) alpha-methylhistamine [(R) alpha-MeHA] and the H3-receptor antagonist thioperamide (Thiop) on basal- and carbachol-stimulated vascular gastrin release (GR) and somatostatin release (SR) by the isolated rat stomach. Carbachol dose-dependently stimulated and inhibited GR and SR, respectively. Maximal stimulation of GR (500 +/- 112 percent...

Intermittent positive pressure ventilation reduces inspiratory muscle electromyographic activity among patients with restrictive ventilatory failure. It has therefore been suggested that the reduction of energy expenditure at night could result in improved inspiratory muscle function during the day. Reported successes with nocturnal ventilation have not included measurements of inspiratory musc...

From 1995 to 1998, more than 90 percent of mid-range IPOs were charged underwriter fees, or spreads, of exactly seven percent, even though evidence suggests that economies of scale in the size of the offering should allow for lower fees. Chen and Ritter (2000) offer collusion as a possible explanation based on empirical analysis and observation. Alternatively, we investigate whether the spreads...

To compare the effectiveness of home versus hospital intravenous (IV) antibiotic therapy for acute pulmonary exacerbations in children with cystic fibrosis (CF). A retrospective chart review was performed of 143 encounters for pulmonary exacerbations in 50 patients with CF. All encounters were categorized into two groups based on location of completion of antibiotic therapy: hospital group comp...

BACKGROUND Adolescence is a period of change, which coincides with disease remission in a significant proportion of subjects with childhood asthma. There is incomplete understanding of the changing characteristics underlying different adolescent asthma transitions. We undertook pathophysiological characterization of transitional adolescent asthma phenotypes in a longitudinal birth cohort. MET...

The data in this note were extracted from claims folders for a sample of student beneficiaries by systematic sampling with a random start from each of 24 student beneficiary strata. These strata reflected 4 age groupings within 2 race groupings within 3 basis-of-entitlement groupings. In each stratum, the student beneficiary population was arranged by social security number, a random start was ...

Communications to the Editor not have active Pneumocystis carinii pneumonia (PCP). All of these patients had a history of single or recurrent episodes of PCP and were receiving aerosolized pentamidine isethionate as prophylaxis against recurrence of PCP It was suspected that the pneumothoraces were caused by coughing due to the irritative effect of pentamidine therapy on the airways superimpose...