Rat pituitary, hypothalamic and cerebral cortical minces are demonstrated to effect the conversion of testosterone (T) to 5~-androstan-17~-ol-3-one (DHT) and A 4androstene-3,17-dione (A4A). The pituitary effected the greatest conversion of T to both DHT and A4A. The hypothalamus converted more T to DHT than did the cerebral cortex; but the conversion of T to ~4A in these two tissues occured to ...

This paper proposes a two-dimensional (2-D) VLSI architecture using a uni ed systolic array for fast computation of the discrete cosine transform/discrete sine transform/discrete Hartley transform (DCT/DST/DHT). The N -point discrete transform is decomposed into evenand oddnumbered frequency samples and they are computed independently at the same time. The proposed uni ed systolic array archite...

Crawling a DHT allows researchers to monitor the behaviour of peers, determine their geographic location, etc. However, it has always been an error-prone process as it is not feasible to capture a full snapshot of the Mainline DHT in a timely manner. Therefore, researchers have developed approximation methods which can run on subsets of the DHT and extrapolate those in order to reason on the si...

In situ estrogen biosynthesis is considered to play pivotal roles in the development and progression of human endometrial carcinoma. However, the biological roles of androgen have remained virtually unknown. Various epidemiological studies have revealed that elevated serum androgen levels are generally associated with an increased risk of developing endometrial carcinoma; however, studies direc...

Noxious stimuli, such as electrical shocks to the animal's tail, enhance Aplysia's gill- and siphon-withdrawal reflex. Previous experimental work has indicated that this behavioral enhancement, known as dishabituation (if the reflex has been habituated) or sensitization (if it has not been habituated), might be mediated, at least in part, by the endogenous monoaminergic transmitter serotonin (5...

The use of consistent hashing to construct a distributed hash table (DHT) has recently gained significant interest from the distributed computing community, particularly because algorithms have been devised which implement a DHT using peer-to-peer (P2P) technology. However a common assumption is that every node that participates in the DHT is within the same transport domain. Some solutions mak...

Environmental androgens are a group of compounds that to date have received very little attention. In this study, a yeast-based androgen screen (YAS) was used to determine the level of in vitro androgenic activity in seven United Kingdom estuaries. Surface water, sediment pore water, and sediment particulate material solvent extracts collected from Southampton Water, the Thames, Mersey, Tees, T...

BACKGROUND Recent reports have described inherent problems with androgen immunoassays compared with mass spectrometry analyses. METHODS We developed a method for measuring serum testosterone (T) and 5alpha-dihydrotestosterone (DHT) simultaneously via liquid-liquid extraction followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) with positive-mode electrospray ionization. RES...

INTRODUCTION Androgenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. However, expert opinions about the usefulness of DHT i...

As reported in the previous paper, dihydrothiamine (DHT), does not seem to be oxidized in biological systems by pyridine nucleotide enzymes or flavin enzymes in view of a high redox-potential of DHT (1). Its possible mecha nism, therefore, is assumed to be oxidation of DHT by a coupled oxidation at a terminal step of the respiratory system by a specific oxidase. Uehara's observation of the oxid...