Ascorbic acid and nitric oxide are known to play important roles in epilepsy. The aim of present study was to identify the involvement of nitric oxide (NO) in the anticonvulsant effects of ascorbic acid on penicillin-induced epileptiform activity in rats. Intracortical injection of penicillin (500, International Units (IU)) into the left sensorimotor cortex induced epileptiform activity within ...

Male albino guinea-pigs of initial body-weight 250 g were used throughout. The experimental conditions, diet and dosing technique were those previously described (Evans & Hughes, 1963). Paired feeding between the normal and the ‘scorbutic’ groups was not practised, as the levels of ascorbic acid given daily (8 and 0.4 mg, respectively) have been shown to have no marked effect on food intake (Ev...

The effects of non-enzymatic antioxidative compounds such as ascorbic acid, thiamine HCl and β-carotene were investigated on salt stressed maize plants. The maize plants were sprayed with 100 mg L of ascorbic acid, thiamine or β-carotene solutions once a week, up to harvesting of plants. The treatment of NaCl was initiated 25 days after sowing by irrigating the plants with 125 mM NaCl solution....

Background: Liposomes constitute a promising drug delivery vehicle, and are believed to improve drugs’ effectiveness. This study was aimed to compare antihypertensive and vascular modifying activities of liposomal and non-liposomal forms of ascorbic acid. Methods: Forty-nine male Sprague-Dawley rats were randomly divided into seven groups (n=7): A sham vehicle-receiving (Sham-veh), hypert...

In this study some selected chemical properties such as total soluble solids, pH, total acidity, formalin index,  reduced sugar content and ascorbic acid of major sour cherry cultivated grown in different provinces of Iran corresponding were investigated.  Minerals K+, Na+, Ca2+, Mg2+, Cu2+, Fe2+ and Zn2+ were determined by graphite furnace atomic absorption spectrophotometer. The result showed...

the purpose of this investigation was to determine the antioxidant potentials and anti-glucosidase activities of six tropical medicinal plants. the levels of phenolic constituents in these medicinal plants were also quantified and compared. antioxidation potentials were determined colorimetrically for scavenging activities against dpph and no radicals. metal chelating assay was based on the mea...

background: the most devastating manifestations of diabetes mellitus are vascular complications. although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. the study was designed t...

Enhanced production of individual phenolic compounds by subcritical water hydrolysis (SWH) of pumpkin leaves was investigated at various temperatures ranging from 100 to 220°C at 20 min and at various reaction times ranging from 10 to 50 min at 160°C. Caffeic acid, p-coumaric acid, ferulic acid, and gentisic acid were the major phenolic compounds in the hydrolysate of pumpkin leaves. All phenol...

The ameliorative activity of aqueous extract of the flesh of dates (Phoenix dactylifera L.) and ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats. Sixty male rats were divided into six equal groups of 10. Two groups were controls, one treated with thioacetamide and one with only distilled water. Two groups received extract of flesh Phoenix dactylifera and intraperitoneal...

Potatoes contain antioxidants such as flavonoids, carotenoids and ascorbic acid. High level consumption worldwide makes potato a valuable source of phytonutrients. Developing new varieties with high nutritional value in combination resistance to pathogens is an important task. In this study, 25 interspecific hybrids Synchytrium endobioticum, common scab, silver rhizoctonia, nematodes PVY were e...