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An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 10(8) red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.

Adenosine but not cytidine at 2 HIMdelayed metaphase some what. Nucleolar reconstruction was retarded in cells after treatment with adenosine, deoxyadenosine, and certain combinations of agents including deoxyribonueleosides. A nucleolar change resembling that induced by adenosine or 6-thioguanine was produced in interphasic cells by a combina tion of deoxyadenosine, deoxyguanosine, and deoxycy...

The transforming activity of DMA isolated from 6-mercaptopurine-treated cultures of Bacillus subtilis strain UTH-8505 is markedly reduced when compared to that of DMA obtained from control cultures. The lower transforming activity appears to be a property of the isolated DNA; i.e., various treatments either to restore the activity or to indicate the presence of inhibitory substances that isolat...