BACKGROUND Common genetic variants in the insulin receptor substrate 1 (IRS1) gene have been recently associated with insulin resistance and hyperinsulinemia. We examined whether the best-associated variant modifies the long-term changes in insulin resistance and body weight in response to weight-loss diets in Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial. METHODS A...

BACKGROUND AND PURPOSE Insulin resistance was common in patients with stroke. This study investigated the association between insulin resistance and outcomes in nondiabetic patients with first-ever acute ischemic stroke. METHODS Patients with ischemic stroke without history of diabetes mellitus in the ACROSS-China registry (Abnormal Glucose Regulation in Patients With Acute Stroke Across Chin...

This study investigated the relationships between measures of fatness and blood insulin and lipids in Taiwanese females living in Taiwan (n=97) or Australia (n=100), and examined the effect of length of residence in Australia on these relationships. Fasting glucose and lipids were determined by Reflotron and fasting insulin using Microparticle Enzyme Immunoassay; insulin resistance (IR) was ide...

There is a need for identifying whether simple techniques estimating visceral fat can accurately predict inflammatory and cardiometabolic disease (CMD) biomarkers in various populations. We aimed to determine estimate of area by multifrequency bioelectrical impedance analysis (MFBIA) was independently associated with multiple inflammation CMD. Seventy-eight men women (mean ± SD: age 52.0 10.8 y...

Purpose: To explore the antidiabetic potential of Moringa oleifera leaf extract in type 2 diabetic rats, and underlying mechanisms.Methods: Streptozotocin (STZ) at a dose 40 mg/kg was given to high fat diet (HFD)- fed rats induce diabetes. M. doses 100, 200 400 were 3 groups rats. The area under curve (AUC) glucose homeostasis model assessment insulin resistance (HOMA-R) calculated using approp...

4.3. (i) Since HomA(A (I),M) ∼= M (I) for a set I and ⊕ is exact, it is clear that HomA(A (I),−) is exact, i.e. A(I) is projective. (ii) “Only if” part: Let A(P ) = ⊕ p∈P Ap be the free A-module indexed by P and ψ : A (P ) → p be the A-homomorphism such that ψ(1p) = p. Then ψ is surjective. If P is projective, then ψ has a section, i.e. an A-homomorphism φ : P → A(P ) such that ψ ◦ φ = idP . Th...

OBJECTIVE To explore visfatin levels and its relationship to obesity, insulin resistance, lipid profile and inflammation in type 2 diabetes mellitus (T2DM) patients with and without macroangiopathy. METHODS The study was designed in the College of Medicine, Qassim University, Qassim, Kingdom of Saudi Arabia, and implemented between April 2006 and May 2007. It involved 84 subjects divided into...

BACKGROUND Adipocytokines are bioactive peptides that may play an important role in the regulation of glucose and lipid metabolism. In this study, we investigated the association of plasma adipocytokine concentrations with markers of triglyceride-rich lipoprotein (TRL) metabolism in men. METHODS Fasting adiponectin, leptin, resistin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alph...