The reliability of the narrative of the Biblical Exodus has been subject of heated debate for decades. Recent archaeological studies seem to provide new insight of the exodus path, and although with a still controversial chronology, the effects of the Minoan Santorini eruption have been proposed as a likely explanation of the biblical plagues. Particularly, it has been suggested that flooding b...

Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering ...

AIMS Hereditary Hemorrhagic Telangiectasia type-1 (HHT1) is a genetic vascular disorder caused by haploinsufficiency of the TGFβ co-receptor endoglin. Dysfunctional homing of HHT1 mononuclear cells (MNCs) towards the infarcted myocardium hampers cardiac recovery. HHT1-MNCs have elevated expression of dipeptidyl peptidase-4 (DPP4/CD26), which inhibits recruitment of CXCR4-expressing MNCs by inac...

During embryonic development, hematopoietic cells develop by a process of endothelial-to hematopoietic transition of a specialized population of endothelial cells. These hemogenic endothelium (HE) cells in turn develop from a primitive population of FLK1 mesodermal cells. Endoglin (ENG) is an accessory TGF-β receptor that is enriched on the surface of endothelial and hematopoietic stem cells an...

Mechanisms of haematopoietic and cardiac patterning remain poorly understood. Here we show that the BMP and Wnt signalling pathways are integrated in an endoglin (Eng)-dependent manner in cardiac and haematopoietic lineage specification. Eng is expressed in early mesoderm and marks both haematopoietic and cardiac progenitors. In the absence of Eng, yolk sacs inappropriately express the cardiac ...

During embryonic development, hematopoietic cells develop by a process of endothelial-to hematopoietic transition of a specialized population of endothelial cells. These hemogenic endothelium (HE) cells in turn develop from a primitive population of FLK1 mesodermal cells. Endoglin (ENG) is an accessory TGF-β receptor that is enriched on the surface of endothelial and hematopoietic stem cells an...

Today, the accumulated volume of data traffic is on the verge of surpassing the accumulated volume of voice traffic in all public networks. Given the growth in the areas of wireless voice and data, we see that the combination of mobile and Internet communication constitutes the driving force behind third-generation wireless systems, which promise to support at least 144 kbit/s (384 kbit/s) in a...

Surface Roughening Using Size-Controllable SiO2 Nanotube Arrays Der-Ming Kuo, Shui-Jinn Wang, Kai-Ming Uang, Tron-Min Chen, Wei-Chi Lee, and Pei-Ren Wang Institute of Microelectronics, Dept. of Electrical Eng., National Cheng Kung Univ., Tainan, Taiwan Department of Electrical Engineering, WuFeng Institute of Technology, Chia-yi, Taiwan *Phone: +886-6-2757575-62351, Fax: +886-6-2763882, E-mail:...

Armando A. Rodriguez ∗ Jeffrey J. Dickeson † Srikanth Sridharan ‡ Akshay Korad § Jaidev Khatri ¶ Dept. of Electrical Eng., Fulton School of Eng., Arizona State University, Tempe, AZ, 85287, U.S.A. Jose Benavides ‖ Don Soloway ∗∗ Guidance, Navigation, and Control, NASA Ames Research Center, Moffett Field, CA, 94035, U.S.A. Atul Kelkar †† Jerald M. Vogel ‡‡ Dept. of Aerospace Eng., College of Eng...