We previously reported that incubation of the appropriat’e sugar nucleotides with extracts obtained from Type XIV Diplococcus pneumoniae resulted in the formabion of glycolipids and serologically active polysaccharides (1, 2). During the course of these studies, we observed the formation of an unusual sugar nucleotide when the extracts were incubated with UDP-N-acetylglucosamine. As shown below...

WR99210 but does not affect the intrinsic activity of proguanil. Proc. Natl. Acad. Sci. U. S. A. 94, 10931–10936 30 Walter, R. etal. (1991) Pyrimethamine-resistantPlasmodiumfalciparum lack cross-resistance to methotrexate and 2,4-diamino-5-(substituted benzyl) pyrimidines. Parasitol. Res. 77, 346–350 31 Cunningham, R.F. et al. (1981) Clinical pharmacokinetics of probenecid. Clin. Pharmacokinet....

It is well-known that tris(8-hydroxyquinoline) aluminum (Alq3) complex and N,N'diphenyl-N,N'-bis(3-methylphenyl)-1,1'- diphenyl-4,4'-diamine compound (TPD) are widely used as electron transfer material (ETL) hole (HTL) in organic light emitting diode (OLED) structure, respectively. Considering the reference materials, present work, OLED performances of some cyclic aromatic structures such 4,4'a...

We report the synthesis of the first 2',3'-diamino substituted uridine derivative with xylo-configuration, its use as starting material for the synthesis of salen-type ligands and the first structurally characterised copper(II) complex thereof.

The susceptibilities of drug-resistant hepatitis B virus (HBV) mutants to lamivudine, adefovir, tenofovir, entecavir, and 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine (PMEO-DAPym), a novel acyclic pyrimidine analogue, were assessed in vitro. Most drug-resistant mutants, including multidrug-resistant strains, remained sensitive to tenofovir and PMEO-DAPym. Therefore, the latter molecule...

Fapy-adenine, Fapy-guanine, Tautomerism, Solvent Effect The results of theoretical geometry prediction of formamidopyrimidine(fapy)-adenine and fapy-guanine tautomers are presented. Among 54 potential tautomeric structures of fapyadenine the most stable structure corresponds to the diamino-keto isomer. The solvent effect has insignificant influence on the fapy-adenine tautomers succession. The ...

The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with formaldehyde through [5 + 1] annulation to afford a novel polycyclic scaffold bearing tetrahydroquinazoline, pyrrolidine, pyrrolidinedione, and N-su...

The whole mol-ecule of the title β-enamino-ester, C(16)H(28)N(2)O(4), is generated by a crystallographic inversion center, situated at the mid-point of the central C-C bond of the 1,4-diamino-butane segment. There are two intra-molecular N-H⋯O hydrogen bonds that generate S(6) ring motifs. This leads to the Z conformation about the C=C bonds [1.3756 (17) Å]. The mol-ecule is S-shaped with the p...