نتایج جستجو برای: 5p deletion

تعداد نتایج: 88488  

Journal: :Molecules 2012
Rong Guo Yi Wang Wei-Ye Shi Bin Liu Sheng-Qi Hou Li Liu

MicroRNA (miRNA) actively participates in a broad range of cellular processes such as proliferation, differentiation, cell survival and apoptosis. Deregulated expression of miRNA may affect cell growth and eventually lead to cancer. In this study, we found that hsa-miR491-5p (miR491-5p) displays a significantly high level of expression in normal human pancreas tissue versus pancreatic cancer ce...

2013
Filipa G. Pinho Adam E. Frampton Joao Nunes Jonathan Krell Heba Alshaker Jimmy Jacob Loredana Pellegrino Laura Roca-Alonso Alexander de Giorgio Victoria Harding Jonathan Waxman Justin Stebbing Dmitry Pchejetski Leandro Castellano

Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset ofmicroRNAs (miRNA,miR) is regulated by estrogen and contributes to cellular proliferation and cancer progression. Here, we describe that miR-515-5p is transcriptionally repressed by estrogen receptora (ERa) and functions as a tumor suppressor in breas...

2017
Jiachun Sun Xiangming Li Wei Wang Wanying Li Shegan Gao Junqiang Yan

MicroRNAs (miRNAs) are small non-coding RNAs that promote the progression of cancer by negatively regulating gene expression. Down-regulation of miR-483-5p was reported in a number of cancers. However, the biological functions of miR-483-5p in esophageal squamous cell carcinomas are not fully understood. In this study, the expression levels of miRNAs in the immortalized human esophageal epithel...

2016
Olivier E Pardo Leandro Castellano Catriona E Munro Yili Hu Francesco Mauri Jonathan Krell Romain Lara Filipa G Pinho Thameenah Choudhury Adam E Frampton Loredana Pellegrino Dmitry Pshezhetskiy Yulan Wang Jonathan Waxman Michael J Seckl Justin Stebbing

Here, we show that miR-515-5p inhibits cancer cell migration and metastasis. RNA-seq analyses of both oestrogen receptor receptor-positive and receptor-negative breast cancer cells overexpressing miR-515-5p reveal down-regulation of NRAS, FZD4, CDC42BPA, PIK3C2B and MARK4 mRNAs. We demonstrate that miR-515-5p inhibits MARK4 directly 3' UTR interaction and that MARK4 knock-down mimics the effect...

2017
Feng Fang Tianqiang Song Ti Zhang Yunlong Cui Gewen Zhang Qingqing Xiong

MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC) progression and are key determinants of prognosis. In this study, we found that miR-425-5p was elevated in HCC and correlated with poor prognostic clinicopathological features and low post-operative long-term survival. Multivariate survival analysis indicated that miR-425-5p expression was an independent risk factor for ov...

2012
Patty B. Garcia Amie Cai Jamie G. Bates Hector Nolla Mark S. Schlissel

Regulated expression of miRNAs influences development in a wide variety of contexts. We report here that miR290-5p (100049710) and miR292-5p (100049711) are induced at the pre-B stage of murine B cell development and that they influence assembly of the Igκ light chain gene (243469) by contributing to the activation of germline Igκ transcription (κGT). We found that upon forced over-expression o...

Journal: :Acta biochimica et biophysica Sinica 2014
Honghai Xu Cong Liu Yuelin Zhang Xiong Guo Zongzhi Liu Zhenqun Luo Yanhai Chang Shizhang Liu Zhengming Sun Xiaoqing Wang

Multiple myeloma (MM) is the most common cause of death from hematological malignancy worldwide, and recent studies have revealed that let-7b-5p can play an inhibitory role in tumorigenesis. However, the role of let-7b-5p in MM still remains unclear. The aim of this study was to elucidate the molecular mechanisms by which let-7b-5p acts as a tumor suppressor in MM. Here, quantitative real-time ...

2016
Chengxia Liu Ming Li Yingbin Hu Ning Shi Haisheng Yu Haiyan Liu Haifeng Lian

Increasing evidence suggests that microRNAs are associated with many important biologic processes in carcinogenesis. Despite ample research revealing the dysregualtion of miR-486-5p in various cancers, little is known about the roles of miR-486-5p in colorectal carcinoma (CRC). In this study, we investigated the biological functions and molecular mechanisms of miR-486-5p in CRC growth and invas...

2017
Xin Zhang Zhi-Hua Ye Hai-Wei Liang Fang-Hui Ren Ping Li Yi-Wu Dang Gang Chen

Our previous research has demonstrated that miR-146a-5p is down-regulated in hepatocellular carcinoma (HCC) and might play a tumor-suppressive role. In this study, we sought to validate the decreased expression with a larger cohort and to explore potential molecular mechanisms. GEO and TCGA databases were used to gather miR-146a-5p expression data in HCC, which included 762 HCC and 454 noncance...

Journal: :Annals of Oncology 2023

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal human cancers chronic hepatitis B virus (HBV) infection accounts for up to 50% total HCC cases worldwide. Although resection surgery has been available as a curative therapy HCC, high rate recurrence remains big threat patient survival. Therefore, discovery valuable biomarkers selecting patients at higher risk key goal allow...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید