An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Safety was evaluated based on adverse events, local sk...

OBJECTIVES To evaluate the 52-week safety/tolerability of oral olanzapine for adolescents with schizophrenia or bipolar mania and compare effectiveness of a standard versus intense behavioral weight intervention in mitigating risk of weight gain. METHODS Patients 13-17 years old with schizophrenia (Brief Psychiatric Rating Scale for Children [BPRS-C] total score >30; item score ≥3 for halluci...

There is an aura about sessions such as this which suggests analogies to a fraternity initiation. Given that, one of the first questions the discussant must ask himself is where his discussion stands in relation to "Hell Week." All of us, I believe, would agree that "Hell Week" is the responsibility of the pledge trainer, or dissertation adviser in this case. If "Hell Week" is over, is the disc...

Background RZB, a humanized immunoglobulin G1 monoclonal antibody that specifically inhibits the p19 subunit of human cytokine IL-23, is being investigated as treatment for PsA. Objectives To compare efficacy and safety RZB vs. placebo (PBO) in patients with PsA who had an inadequate response or intolerance to conventional synthetic disease modifying antirheumatic drug (csDMARD-IR). Methods KEE...

Abstract Background In ulcerative colitis (UC), persistent histological activity is associated with higher rates of relapse and long-term complications, even when endoscopic remission achieved; therefore, healing a potentially important treatment target. Etrasimod an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 (S1P1,4,5) modulator for the moderately to se...