1 RECIPROCAL INTERACTIONS REGULATE TARGETING OF CALCIUM CHANNEL β SUBUNITS AND MEMBRANE EXPRESSION OF α1 SUBUNITS IN CULTURED HIPPOCAMPAL NEURONS* Gerald J. Obermair, Bettina Schlick, Valentina Di Biase, Prakash Subramanyam, Mathias Gebhart, Sabine Baumgartner and Bernhard E. Flucher From Department of Physiology and Medical Physics, Innsbruck Medical University, and Department of Pharmacology ...

This paper presents the design and analysis of an area efficient implementation of the SHA-3 candidate Blue Midnight Wish hash function with different digest sizes of 256 and 512 bits on an FPGA platform. The core functionality with finalization implementation without padding stage of BMW on Xilinx Virtex-5 FPGA requires 51 slices for BMW256 and 105 slices for BMW-512. Both BMW versions require...

T w o finishing trials were conducted to measure the response of cattle adjusting to high-concentrate diets to dietary monensin level. In trial 1, 54 individually fed Hereford-Angus steers (312 kg), previously fed a two-thirds corn silage: one-third corncob-based diet, were allotted in a 2 • 3 factorial arrangement of treatment with tylosin (0, 11 mg/kg) and monensin (0, 11, 33 mg/kg) fed durin...

[This corrects the article DOI: 10.1371/journal.pone.0154234.].

In a group of IS anesthetized dogs hepatic blood flow measured by the BSP removal technio of Bradley and the radioactive colloidal chromic phosphate disappearance method of Dobson gave comparable results of 3S.7 and 38.3 liil./Kg./niin. respectively. In response to acute hemorrhage of 25 ml./Kg., hepatic blood flow fell from 42.3 to 35.4 ml./Kg. A more severe hemorrhage of"33 ml./Kg. produced a...

In a group of IS anesthetized dogs hepatic blood flow measured by the BSP removal technio of Bradley and the radioactive colloidal chromic phosphate disappearance method of Dobson gave comparable results of 3S.7 and 38.3 liil./Kg./niin. respectively. In response to acute hemorrhage of 25 ml./Kg., hepatic blood flow fell from 42.3 to 35.4 ml./Kg. A more severe hemorrhage of"33 ml./Kg. produced a...

INTRODUCTION The need for the rational development of newer and adjuvant drugs to treat epilepsy has prompted this study of the potential anticonvulsant effect of amlodipine. METHODS The acute effect was studied in mice in single doses of 1 mg/kg, 2 mg/kg and 4 mg/kg of amlodipine and the chronic effect was studied in doses of 1 mg/kg and 4 mg/kg (administered daily for 21 days) using the max...

Single-dose trovafloxacin (15 mg/kg given intravenously [i.v.]) and ampicillin (40 mg/kg given i.v.) protected 38 and 33% of animals challenged with an ampicillin-tolerant strain of Streptococcus oralis, respectively. As a double-dose regimen, trovafloxacin afforded total protection (100%; P < 0.001 versus controls). Trovafloxacin is the first fluoroquinolone effective in preventing experimenta...