Introduction: the context of Covid-19 pandemic in Brazilian North region is worrying. There a lack resources for Public Health, low human development index, and poverty indicators above national average. Objective: to analyze mortality lethality from COVID-19 State Roraima, Brazil. Methods: this an ecological time-series study secondary data on Northern Brazil, March 2020 July 2021. The inciden...

The presence of flavonoids in white pitaya’s flesh and peel was confirmed using the Thin Layer Chromatography Screening method. Flavonoid extracted solvent fractionation then subjected to three assays. Using Kirby-Bauer method, better antibacterial activity against E. coli found 100% extract, partially active at 10.28 mm. flavonoid extract inactive both S. aureus concentrations 100%, 75%, 50%. ...

This study aims to assess the comparative cytotoxic activity of ethanolic extract Mikania cordata (MC), micrantha (MM) and scandens (MS) (Family: Asteraceae) using brine shrimp lethality bioassay colorimetric sulforhodamine B assay method. In SRB assay, A549 human lung carcinoma, SK-Mel-2 skin melanoma B16F1 mouse cell lines were used. LC50 for MC, MM, MS vincristine found be 29.04, 15.84, 32.3...

Some circularized X-Y chromosomes in Drosophila melanogaster are mitotically unstable and induce early embryonic lethality, but the genetic basis is unknown. Our experiments suggest that a large region of X-linked satellite DNA causes anaphase bridges and lethality when placed into a new heterochromatic environment within certain circularized X-Y chromosomes. These results reveal that repetitiv...

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Although internal abdominal hernias cause acute intestinal obstruction in no more than 6% of cases, the lethality associated with them reaches 50% in case of untimely diagnosed strangulation and gangrene of the intestine. The rarest type of such hernias is a transomental hernia, which occurs in 1-4% of cases. The diagnosis is difficult when such hernias are strangulated; therefore, they require...

We report that the anticancer activity of the widely used diabetic drug metformin is strongly potentiated by syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to syrosingopine's known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α-enolase ...

We have identified a novel human gene by virtue of its ability to complement the radl-1 checkpoint mutant of Schizosaccharomyces pombe. This gene, called RACH2, rescues the temperature-sensitive lethality of a radl-1 weel-50 double mutant of S. pombe. Expression of RACH2 in S. pombe radl-1 strains partially restores UV resistance to the radl-1 mutant strain. Expression of RACH2 in a radl-1 cdc2...

Systematic analysis of synthetic lethality (SL) constitutes a critical tool for systems biology to decipher molecular pathways. The most accepted mechanistic explanation of SL is that the two genes function in parallel, mutually compensatory pathways, known as between-pathway SL. However, recent genome-wide analyses in yeast identified a significant number of within-pathway negative genetic int...

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of...