The human and mouse RefSec database of mRNAs for protein tyrosine phosphatases (PTPs) was searched. The positions of the uAUG and uORF within the 5’untranslated region (5’UTR) were compared. It was shown that the uAUGs in all PTPs are conserved very strongly, suggesting the presence of a mechanism for translation down regulation. The uORFs in the receptor type PTPs, in contrast to the non-trans...

An analysis of published nucleotide sequences of the 5'-untranslated region (5'-UTR) of 7 cardioviruses and 3 aphthoviruses has allowed us to derive a consensus secondary structure model that differs from that previously proposed for the 5'-UTR of entero- and rhinoviruses, though all these viruses belong to the same family, Picornaviridae. The theoretical model derived here was experimentally s...

Background: In the yeast Saccharomyces cerevisiae, as in every eukaryotic organism, the mRNA 5′-untranslated region (UTR) is important for translation initiation. However, the patterns and mechanisms that determine the efficiency with which ribozomes bind mRNA, the elongation of ribosomes through the 5′-UTR, and the formation of a stable translation initiation complex are not clear. Genes that ...

BACKGROUND In the yeast Saccharomyces cerevisiae, as in every eukaryotic organism, the mRNA 5'-untranslated region (UTR) is important for translation initiation. However, the patterns and mechanisms that determine the efficiency with which ribozomes bind mRNA, the elongation of ribosomes through the 5'-UTR, and the formation of a stable translation initiation complex are not clear. Genes that a...

The 5' untranslated region (5'UTR) of lentiviral genomic RNA is highly structured, and is the site of multiple RNA-RNA and RNA-protein interactions throughout the viral life cycle. The 5'UTR plays a critical role during transcription, translational regulation, genome dimerization, reverse transcription priming and encapsidation. The 5'UTR structures of human lentiviruses have been extensively s...