Including this studying synthesis, characterization and antimicrobial evaluation of a new series Mannich base derivatives containing 1,3,4-oxadiazole system The novel compounds synthesis by the reaction 1,3,4-oxadiazole-2-thiol with various secondary amine formaldehyde, structures newly synthesized were confirmed FT.IR 1HNMR spectral data. Invitro anti-microbial activity was evaluated agar nutr...

In the title 1,2,4-oxadiazole derivative, C(19)H(18)ClN(3)O(3), the 1,2,4-oxadiazole ring makes dihedral angles of 12.83 (8) and 4.89 (8)°, respectively, with the benzyl and 4-chloro-phenyl rings, while the dihedral angle between the benzyl and 4-chloro-phenyl rings is 11.53 (7)°. In the crystal, mol-ecules are linked by N-H⋯N hydrogen bonds into helical chains along the b axis. A weak C-H⋯π in...

The title ionic compound, C16H36N(+)·C10H20B10N3O3(-), consists of a tetra-butyl-ammonium cation and a closo-deca-borate cluster anion, which is bound to the substituted 2,3-dihydro-1,2,4-oxadiazole ring through a B-N bond [1.540 (2) Å]. The distances between connected B atoms in the deca-borate cluster range from 1.689 (2) to 1.844 (2) Å. The 2,3-dihydro-1,2,4-oxadiazole ring adopts an envelop...

Binding of several nitroheterocycles by mammalian cells is a function of the ambient oxygen concentration; anoxic single cells bind up to 10 times as much of these drugs as do aerobic cells. We thus hypothesized that fluorescent nitroheterocyles could be used to quantitate the fraction of hypoxic cells in multicell systems, and this was tested in multicell spheroids using a relatively nontoxic ...

benzodiazepines are useful drugs for treatment of sleep disorders, anxiety, seizure cases and skeletal muscle cramps. some derivatives of 2-(2-phenoxy) phenyl-1, 3, 4-oxadiazole were synthesized as benzodiazepine receptor agonists. conformational analysis and superimposition of energy minima conformers of the compounds on estazolam, a known benzodiazepine agonist, reveal that the main proposed ...

The structure of the oxadiazole skeleton is a biologically and biochemically active nucleus that has multiple number biological activities. five-membered aromatic ring been used in numerous studies molecules synthesised laboratories. principle Oxadiazole with pair Pyridine-type nitrogen atoms confirmed to be valuable for analogues having efficacious protein interactions large enzyme proteins re...

A number of new 5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazole derivatives, 2-5 and 8-11, were synthesized. The 2-{5-[(naphthalen-5-yloxy)methyl]-1,3,4-oxadiazol-2-ylthio}acetohydrazones 6a and 6b were synthesized by the reaction of the hydrazide 4 with the corresponding monosaccharides. Cyclization of the sugar hydrazones 6a and 6b with acetic anhydride afforded the substituted oxadiazoline d...