Stato di avanzamento Dall’Aprile 2012 ad oggi sono stati esaminati 29 soggetti con nuova diagnosi di Sclerosi Multipla/CIS e sottoposti al protocollo suddetto. Un’analisi statistica in itinere relativa al profilo cognitivo della popolazione in studio alla baseline ha consentito di rilevare una maggiore compromissione delle funzioni esecutive in un sottogruppo di pazienti affetti da malattia cli...

Cyclic bis(3'-5')diguanylic acid (cyclic-di-GMP) functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes. We measured cyclic-di-GMP and its structural analogs such as cyclic bis(3'-5')guanylic/adenylic acid (cyclic-GpAp), cyclic bis(3'-5')guanylic/inosinic acid (cyclic-GpIp) and monophosphorothioic acid of cyclic-di-GMP (cyclic-GpGps) for eff...

A. Di Virgilio, L. Barsotti, S. Braccini, C. Bradaschia, G. Cella, V. Dattilo , M. Del Prete, I. Ferrante, F. Fidecaro, I. Fiori, F. Frasconi, A. Gennai, A. Giazotto, P. La Penna, G.Losurdo , E. Majorana, M. Mantovani , F. Paoletti, R. Passaquieti, D. Passuello, F. Piergiovanni, A. Porzio, P. Puppo, F. Raffaelli, P. Rapagnani, F. Ricci, S. Solimeno, G. Vajente, F. Vetrano INFN, Sez. di Pisa, Pi...

Thüringer Landessternwarte Tautenburg, Sternwarte 5, D–07778 Tautenburg, Germany Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 Department of Astronomy, University of Texas, Austin, TX 78712, USA Townes Fellow, Space Sciences Laboratory, University of California, Berkeley, CA, 94720-7450, USA Astronomy Department, University of California, 445 Campbell Hall, Berk...

Of the DNA bases, peroxynitrite (ONOO-) is most reactive toward 2'-deoxyguanosine (dGuo), but even more reactive with 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodGuo), requiring a 1,000-fold excess of dGuo to provide 50% protection against the reaction with 8-oxodGuo. Therefore, it seems reasonable that 8-oxodGuo is a potentially important target in DNA and that the structures of the reaction p...

While the 5' cis-acting sequence of mouse hepatitis virus (MHV) for genomic RNA replication has been determined in several defective interfering (DI) RNA systems, it remains elusive for subgenomic RNA transcription. Previous studies have shown that the leader RNA in the DI genome significantly enhances the efficiency of DI subgenomic mRNA transcription, indicating that the leader RNA is a cis-a...

Neda Ghofraniha, Claudio Conti, Giancarlo Ruocco, Stefano Trillo 1 Research Center SMC INFM-CNR, Università di Roma “La Sapienza”, P. A. Moro 2, 00185, Roma, Italy Centro Studi e Ricerche “Enrico Fermi”, Via Panisperna 89/A, 00184 Rome, Italy Research center SOFT INFM-CNR Università di Roma “La Sapienza”, P. A. Moro 2, 00185, Roma, Italy Dipartimento di Fisica, Università di Roma “La Sapienza”,...

Andrea Rocchetto,1, 2, ∗ Scott Aaronson,3 Simone Severini,1, 4 Gonzalo Carvacho,5 Davide Poderini,5 Iris Agresti,5 Marco Bentivegna,5 and Fabio Sciarrino5, † 1Department of Computer Science, University College London, London, UK 2Department of Materials, University of Oxford, Oxford, UK 3Department of Computer Science, University of Texas at Austin, Austin, USA 4Institute of Natural Sciences, S...

Turnip crinkle virus is one of several single-stranded RNA plant viruses associated with defective interfering (DI) RNAs. A complete cDNA copy of a 344-base DI RNA (DI RNA G) was cloned downstream from a T7 RNA polymerase promoter. Transcripts synthesized in vitro were infectious when inoculated with helper virus on turnip plants. Studies of the infectivity of DI transcripts containing deletion...