The photoexcited dynamics of a laser dye, 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM), in an acetonitrile solution and dimethyl sulfoxide (DMSO) were studied by pump–probe spectroscopy with 6-fs ultraviolet laser. UV light excites the DCM solved any or DMSO into locally excited (LE) state (via S0→S2 excitation), then LE relaxes to charge transfer state. In previous st...

Previously, we showed that the crude methanol extracts of Leucas indica flowers exhibited antioxidant properties and in current study, flower L. anticancerous as evidenced cytotoxicity (MTT assay test) against selected cancerous cell lines HeLa, HCT116, HL-60, MCF-7. Therefore, further analysis was performed to isolate purify bioactive compound using activity-guided repeated fractionation extra...

The intermediate-conductance Ca2+-activated K+ channel (KCa3.1) constitutes an attractive pharmacological target for immunosuppression, fibroproliferative disorders, atherosclerosis, and stroke. However, there currently is no available crystal structure of this medically relevant channel that could be used for structure-assisted drug design. Using the Rosetta molecular modeling suite we generat...

Organic solid-state tri-wavelength lasing was demonstrated from dye-doped holographic polymer-dispersed liquid crystal (HPDLC) distributed feedback (DFB) laser with semiconducting polymer poly[-methoxy-5-(2'-ethyl-hexyloxy)-1,4-phenylene-vinylene] (MEH-PPV) and laser dye [4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran] (DCM) by a one-step holography technique, which centered a...

The asymmetric unit of the title compound, C(18)H(17)ClN(2)O(2)·0.5H(2)O, contains two organic mol-ecules and one solvent water mol-ecule. In each organic mol-ecule, the cyclo-hexene ring adopts an envelope conformation with the C atom connecting the two methyl groups on the flap; the 4H-pyran ring is nearly planar [maximum deviation = 0.113 (3) Å in one mol-ecule and 0.089 (3) Å in the other m...