نتایج جستجو برای: 468

تعداد نتایج: 3255  

2014
Theera Srisawat Yaowapa Sukpondma Siriphon Chimplee Kanyanatt Kanokwiroon Aman Tedasen Potchanapond Graidist

Very strong antiproliferative action of V. diospyroides type SS fruit extracts (IC50 range of 1.60-17.45 µg/mL) in MDA-MB-468 cell-line was observed in an MTT assay. After dosing of an extract concentration at half IC50 to cell line for 24 to 72 hours, treated cells were subjected to Annexin V-FITC/PI binding assay, followed by FACS and western blot analyses. Significant apoptotic death was obs...

2016
Chun-Yu Liu Ming-Hung Hu Chia-Jung Hsu Chun-Teng Huang Duen-Shian Wang Wen-Chun Tsai Yi-Ting Chen Chia-Han Lee Pei-Yi Chu Chia-Chi Hsu Ming-Huang Chen Chung-Wai Shiau Ling-Ming Tseng Kuen-Feng Chen

We tested the efficacy of lapatinib, a dual tyrosine kinase inhibitor which interrupts the HER2 and epidermal growth factor receptor (EGFR) pathways, in a panel of triple-negative breast cancer (TNBC) cells, and examined the drug mechanism. Lapatinib showed an anti-proliferative effect in HCC 1937, MDA-MB-468, and MDA-MB-231 cell lines. Lapatinib induced significant apoptosis and inhibited CIP2...

2015
Potchanapond Graidist Mananya Martla Yaowapa Sukpondma

This study aimed to evaluate the cytotoxicity of a crude extract of Piper cubeba against normal and breast cancer cell lines. To prepare the extract, P. cubeba seeds were ground, soaked in methanol and dichloromethane and isolated by column chromatography. Fractions were tested for cytotoxicity effects on normal fibroblast (L929), normal breast (MCF-12A) and breast cancer cell lines (MCF-7, MDA...

2015
XINZHAO WANG HONGKUAN SONG QIAN YU QI LIU LEILEI WANG ZHAOYUN LIU ZHIYONG YU

Triple-negative breast cancer (TNBC) accounts for 20% of all molecular subtypes of breast cancer. Neither endocrine nor anti-HER2 molecular targeting treatment yield promising results. At present, epidermal growth factor receptor (EGFR) inhibitor, as a single agent, is unable to obtain encouraging results in the treatment of TNBC, even though most of these tumors overexpress EGFR. In the presen...

2016
Hatem A. Abdel-Aziz Wagdy M. Eldehna Hazem Ghabbour Ghada H. Al-Ansary Areej M. Assaf Abdullah Al-Dhfyan

On account of its poor prognosis and deficiency of therapeutic stratifications, triple negative breast cancer continues to form the causative platform of an incommensurate number of breast cancer deaths. Aiming at the development of potent anticancer agents as a continuum of our previous efforts, a novel series of 2-((benzimidazol-2-yl)thio)-1-arylethan-1-ones 5a-w was synthesized and evaluated...

2012
Carina Strell Bernd Niggemann Melanie J. Voss Desmond G. Powe Frank Entschladen

The migratory activity of tumor cells and their ability to extravasate from the blood stream through the vascular endothelium are important steps within the metastasis cascade.We have shown previously that norepinephrine is a potent inducer of the migration ofMDA-MB-468 human breast carcinoma cells and therefore investigated herein, whether the interaction of these cells as well as MDA-MB-231 a...

2014
Mikako Takeshima Misaki Ono Takako Higuchi Chen Chen Takayuki Hara Shuji Nakano

Although lycopene, a major carotenoid component of tomatoes, has been suggested to attenuate the risk of breast cancer, the underlying preventive mechanism remains to be determined. Moreover, it is not known whether there are any differences in lycopene activity among different subtypes of human breast cancer cells. Using ER/PR positive MCF-7, HER2-positive SK-BR-3 and triple-negative MDA-MB-46...

Journal: :British medical journal 1963
N H Hills J S Calnan J J Pflug K Jeyasingh

When is Dementia Presenile? J. A. Snowdon, M.R.A.C.P.; P. K. Bridges, M.D., D.P.M ............................. 465 Research in Psychiatry C. P. B. Brook, D.P.M.; A. Tarnopolsky, M.D. 465 Speaking Valve for Alttachment to a Tracheostomy Tube F. M. Emery, F.F.A. R.C.S ................. 466 Effect of Intravenous Infusion of Acetylsalicylic Acid on Renal Function M. Robert, and others ...............

2012
Rita Arabsolghar Mozhgan Rasti

BACKGROUND Electroporation is a valuable tool for small interfering RNA (siRNA) delivery into cells because it efficiently transforms a wide variety of cell types. Since electroporation condition for each cell type must be determined experimentally, this study presents an optimal electroporation strategy to reproducibly and efficiently transfect MDA-MB 468 human breast cancer cell with siRNA. ...

2016
Wei-Xia Lin Han-Shi Zeng Zhan-Hui Zhang Man Mao Qi-Qi Zheng Shu-Tao Zhao Ying Cheng Feng-Ping Chen Wang-Rong Wen Yuan-Zong Song

Citrin deficiency (CD) is a Mendelian disease due to biallelic mutations of SLC25A13 gene. Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is the major pediatric CD phenotype, and its definite diagnosis relies on SLC25A13 genetic analysis. China is a vast country with a huge population, but the SLC25A13 genotypic features of CD patients in our country remains far from bein...

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