BACKGROUND Twin studies have shown that age at menarche may be subject to hereditary influences but the specific determinants are unknown. Estrogens are known to have an important role in menarche. Since the enzyme aromatase is responsible for the conversion of androgens to estrogens, the aromatase (CYP19) gene could be a candidate gene for the regulation of menarche. The aim of this study was ...

OBJECTIVE The efficacy and safety of height-limiting therapy with high-dose 17beta-oestradiol in girls with constitutionally tall stature (CTS) are controversial. We evaluated the effectiveness of high-dose 17beta-oestradiol in premenarchal girls with CTS treated until their bone age reached 14 years. DESIGN We retrospectively reviewed the medical records of the girls managed between 1989 and...

The mean and median age at menarche in 360 Khasi girls was found to be 13.22 ± 0.88 and 12.13 ± 0.79 years, respectively; socio-economic status was observed to be a strong predictor of age at menarche in this population.

OBJECTIVE To determine the efficacy of a 2-year obesity prevention program in African American girls. DESIGN Memphis GEMS (Girls' health Enrichment Multi-site Studies) was a controlled trial in which girls were randomly assigned to an obesity prevention program or alternative intervention. SETTING Local community centers and YWCAs (Young Women's Christian Associations) in Memphis, Tennessee...

BACKGROUND The effect of the increasing prevalence of obesity on blood pressure (BP) secular trends is unclear. We analyzed BP and body mass index secular trends between 1998 and 2006 in children and adolescents of the Seychelles, a rapidly developing island state in the African region. METHODS AND RESULTS School-based surveys were conducted annually between 1998 and 2006 among all students i...

BACKGROUND Prediction of the onset of menstruation (menarche age) using height, weight and Body Mass Index (BMI) is a major health procedure. The present study was conducted to determine the relationship between anthropometric indices and menarche age in 488 girls 11-17 years in southern Iran (Kish Island) in 2011. METHODS Data was collected using questionnaires as well as measurements of the...

conclusions the prevalence of astigmatism was high in children under six years old in this study, and to control amblyopia, it is necessary to consider astigmatism at younger ages. results the prevalence of refractive astigmatism of more than 0.5d in at least one eye was 51.4% (95% confidence interval (ci): 50.7-52.1); 52.1% in girls and 50.7% in boys (p = 0.412). prevalence of astigmatism decr...

Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of ...