The objective of the present investigation was to study the effect of polyethylene glycol 4000 (PEG 4000) on in vitro dissolution of gliclazide from solid dispersions. Initial studies were carried out using physical mixtures of the drug and carrier. Solid dispersions were prepared by the melting or fusion method.Phase and saturation solubility study, in vitro dissolution of pure drug, physical ...

Gliclazide is a second-generation hypoglycaemic sulfonylurea that is useful in the treatment of Type 2 diabetes mellitus. It shows low aqueous solubility and dissolution rate and often shows low and irregular bioavailability after oral administration. This paper describes an approach to improve the Solubility of gliclazide by using solid dispersions (SDs) in polyethylene glycol 4000 (PEG 4000)....

BACKGROUND SoundTracker is an algorithm in Widex's Compass fitting software that could potentially be used to estimate a patient's aided sensation level (SL). SoundTracker's accuracy of estimating a patient's SL has never been verified in comparison to SL measured with commercially available real-ear analyzers. PURPOSE Determine whether statistically significant differences are present betwee...

An experiment was conducted, from 22 to 42-d-post-hatch, to evaluate the effect of different combinations of carbohydrases (CHS), citric acid (CA) and high-dose phytase in wheat-canola meal-based diets with very low content of non-phytate phosphorus (NPP) on growth performance, plasma calcium (Ca) and P and tibia ash (TA) content of broiler chickens. One hundred and ninety two 21-d-old male chi...

The widespread interest in provider-provisioned Virtual Private Network (VPN) solutions lead to memos proposing different and overlapping solutions. The IETF working groups (first Provider Provisioned VPNs and later Layer 2 VPNs and Layer 3 VPNs) have discussed these proposals and documented specifications. This has lead to the development of a partially new set of concepts used to describe the...

When designing asynchronous systems, the problems of hazards becomes an important issue. This paper deals with the hazard-free implementation of asynchronous logic in a look-up table based FPGA. First, the definitions of hazards and techniques to deal with them in gate-level asynchronous circuits are surveyed. Then the look-up table (LUT) model and its associated timing properties are presented...

The goal of this paper is to enhance the Chartalist approach to the origin of money, by embedding it in the concrete historical and socioeconomic circumstances of ancient societies, such as Ancient Mesopotamia ca. 4000 B.C. to 2500 B.C. It will be argued, that given the absence of bureaucratic tools such as writing, census systems and formal means of personal identification to detect those with...

InfiniBand is a switched fabric interconnect. The InfiniBand specification does not define an API. However the OFED package, libibverbs, has become the default API on Linux and Solaris systems. Sparse documentation exists for the verbs API. The simplest InfiniBand program provided by OFED, ibv rc pingpong, is about 800 lines long. The semantics of using the verbs API for this program is not obv...

* Correspondence: hassen. [email protected] Institut Supérieur d’Informatique et des Technologies de Communication de Hammam Sousse, Université de Sousse, Route GP1-4011, Hammam Sousse, Tunisie Full list of author information is available at the end of the article Abstract In this article, we prove a general common fixed point theorem for two pairs of weakly compatible self-mappings of a partia...

State-of-the-art FPGAs are just capable of implementing PCI bus initiator and target functions at the original bus speed of 33 MHz. This paper reports on the use of a Xilinx 4000 series FPGA and LogiCore macros to implement a fully compliant PCI card for a specialist data acquisition application. The design required careful performance analysis and manual intervention during the design process ...