Tetrazole-containing compounds have been the subject of much recent research because of theirpotential as high energy density materials (HEDMs). In this work, theoretical studies on the 1Htetrazolylderivatives of tetrahedrane were done at the density functional theory (DFT) method withthe 6-31G(d) basis set without any symmetrical restrictions in order to find the structural andenergetically pr...

Division of application No. 09/411,919, filed on Oct. 4, 1999, which is a continuation-in-part of application No. 09/385,615, filed on Aug. 30, 1999, now Pat. No. 6,132,210, which is a continuation of application No. 09/082,030, filed on May 20, 1998, now Pat. No. 5,961,324. Provisional application No. 60/120,612, filed on Feb. 18, 1999, provisional application No. 60/109,299, filed on Nov. 19,...

alizing large 3D data sets from scientific or medical applications. Transfer functions are particularly important to the quality of direct volume-rendered images. A transfer function assigns optical properties, such as color and opacity, to original values of the data set being visualized. Unfortunately, finding good transfer functions proves difficult. Pat Hanrahan called it one of the top 10 ...

This work involved the synthesis of tetrazole derivatives 4,4'-(((sulfonylbis(4,1-phenylene))bis(diazene-2,1-dil))bis(2-(1-(4-R)phenyl]-4),5-Dihydro-1H-tetrazol-5-yl(phenol) (where R = OH or OCH3) through reaction substituted amine in THF as a solvent, with sodium azide. FT-IR 1H-NMR Spectrophotometric methods were used to characterize prepared compounds, antibacterial activity against four typ...

MNTI is a rare tumor of indeterminate histogenesis and molecular signature. We performed methylation copy number variation (CNV) profiles in patients with (n = 7) PAT 1) compared to the brain classifier v11b4 (BT-C) medulloblastoma (MB) group 3/4 v1.0 (MB3/4-C). The patients’ mean age was 8 months (range: 4–48). BT-C classified five MNTIs one (relapse) as class family MB-G3/G4, subclass 3 (scor...

Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in an effort to improve half-life. We identify a hydroxamate tetrazole 4e that spares MMP-1 and -14, shows >400-fold selectivity versus MMP-8 and >600-...

The general advantages of parallel acquisition techniques (PAT) for clinical MRI are the possibilities for either a higher spatial resolution or shorter scan times which subsequently allow shorter breath holds or multiple averaging within the same total scan time. Due to the shorter echo-trains, less blurring and image distortion is found in single-shot applications such as HASTE or EPI. Shorte...

STUDY OBJECTIVES One of the most important caveats of ambulatory devices is the inability to record and stage sleep. We assessed an algorithm determining 4 different stages: wake, light sleep, deep sleep, and REM sleep using signals derived from the portable monitor Watch-PAT100 (PAT recorder). METHODS Participants (38 normal subjects and 189 patients with obstructive sleep apnea [OSA]) under...