In tumor dormancy, tumor cells persist in the host over a long period of time but do not grow. We investigated in the DA1-3b mouse model of acute myeloid leukemia how leukemic cells could persist for months in spite of an effective antileukemic immune response. Mice were immunized with irradiated interleukin 12 (IL12)- or CD154-transduced DA1-3b cells, challenged with wild-type DA1-3b cells, an...

Purpose: To synthesize a new series of 1-substituted-4-(pyridin-4-yl) [1,2,4] triazolo[4,3-a]quinazolin5(4H)-ones and evaluate them for H1-antihistaminic activity with negligible side effects in guinea pigs. Methods: The synthesized compounds were characterized by Infrared spectroscopy (IR), proton nuclear magnetic resonance (H-NMR) and mass spectrometry (MS) data. The purity of the compounds w...

Using Monte Carlo methods and finite-size scaling, we investigate surface critical phenomena in the bond-percolation model on the simple-cubic lattice with two open surfaces in one direction. We decompose the whole lattice into percolation clusters and sample the surface and bulk dimensionless ratios Q1 and Qb, defined on the basis of the moments of the cluster-size distribution. These ratios a...

Histone H1 plays a crucial role in stabilizing higher order chromatin structure. Transcriptional activation, DNA replication, and chromosome condensation all require changes in chromatin structure and are correlated with the phosphorylation of histone H1. In this study, we describe a novel interaction between Pin1, a phosphorylation-specific prolyl isomerase, and phosphorylated histone H1. A su...

A highly specific aggregation factor for Streptococcus sanguis H1 (AFH1) was obtained by lysozyme treatment of Actinomyces viscosus T14V. At 1 micrograms/ml, AFH1 aggregated a suspension of S. sanguis H1, with which A. viscosus T14V coaggregates by a mechanism not inhibited by lactose: even at much higher levels AFH1 caused little or no aggregation of streptococci from other coaggregation group...

Heparanase is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains of heparan sulfate proteoglycans (HSPG). Specifically, the cell surface HSPG syndecan-1 and -4 (SDC1 and SDC4) aremodulators of growth factor action, and SDC4 is implicated in cell adhesion as a key member of focal adhesion complexes. We hypothe...