Reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. Substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methy...

Tamarindus indica is one of the medicinal plants used in treatment various diseases traditionally.
 Aims: This study was conducted to identify phytochemical constituents T. leaf extracts. Methods: Using Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography-mass spectrometry (GC-MS) identification bioactive compounds extracts indica.
 Results: The FT-IR spectrum confir...

A new flavonoid identified as 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-4H,8H-pyrano[2,3-f]chromen-4-one (2'-hydroxyatalantoflavone) (1) was obtained from the roots of Milicia excelsa along with five known compounds including atalantoflavone (2), neocyclomorusin (3), 6-geranylnorartocarpetin (4), cudraxanthone I (5), and betulinic acid (6). The structures of the isolates were established o...

Premutation CGG repeat expansions (55-200 CGG repeats; preCGG) within the fragile X mental retardation 1 (FMR1) gene cause fragile X-associated tremor/ataxia syndrome (FXTAS). Defects in neuronal morphology and migration have been described in a preCGG mouse model. Mouse preCGG hippocampal neurons (170 CGG repeats) grown in vitro develop abnormal networks of clustered burst (CB) firing, as asse...

The pharmacokinetic behavior of three iron chelators based on the desferrithiocin (DFT) pharmacophore, (S)-4, 5-dihydro-2-(2-hydroxyphenyl)-4-thiazolecarboxylic acid (desmethyldesferrithiocin, DMDFT, 2); (S)-4,5-dihydro-2-(2, 4-dihydroxyphenyl)-4-thiazolecarboxylic acid [4-(S)-hydroxydesazaDMDFT, 3); and (R)-2-(2-hydroxyphenyl)-4-oxazolinecarboxylic acid, the oxazoline analog of desazaDMDFT, 4,...

Plants are excellent sources of secondary metabolites that have been used for the treatment human diseases. The plant Momordica cymbalaria contains different types phytochemicals like phenols, steroids, flavonoids, alkaloids and tannins. present investigation was carried out to determine bioactive compounds in parts by Gas chromatography- Mass spectroscopy (GC-MS) technique. Chromatograms vivo ...

Arnica montana L. is an alpine herbaceous plant typical of nutrient-poor grasslands. It a popular medicinal for the treatment bruises, cuts and pain, it also endangered species. For this reason, sustainable production inflorescences instead spontaneous collection material, coupled with use local ecotypes, should be incentivized. Inflorescences wild accession arnica were compared versus cultivat...