An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1,4-dihydropyridines with different substituents at the 1-, 3-, 4- and 5-positions. Microwaves improved the reaction yield, reducing also considerably the reaction time and the amount of solvent used. Chiral primary amines gave chiral 1-substituted-1,4-dihydropyridines. The 4-(1-naphth...

The title compound, C(25)H(16)Cl(2)N(4), has intra-molecular N-H⋯N and C-H⋯Cl hydrogen bonds. In the crystal structure, mol-ecules are linked through N-H⋯N hydrogen bonds, forming a centrosymmetric R(2) (2)(16) dimer.

Muscular dysgenesis (mdg) is a lethal autosomal, recessive mutation of mice. Skeletal muscle from dysgenic mice is paralyzed due to the failure of excitation-contraction (E-C) coupling. Considerable evidence indicates that this failure results from the absence of a specific gene product, the alpha 1 subunit of the skeletal muscle receptor for dihydropyridine calcium channel modifiers. This dihy...

Antibodies against the subunits of the dihydropyridine-sensitive L-type calcium channel of skeletal muscle were tested for their ability to immunoprecipitate the high affinity (ICd = 0.13 nM) "'I-w-conotoxin GVIA receptor from rabbit brain membranes. Monoclonal antibody VD21 against the B subunit of the dihydropyridine receptor from skeletal muscle specifically immunoprecipitated up to 86% of t...

Ten synthetic dihydropyridine analogues were investigated for their ability to reverse drug resistance in a multidrug-resistant human carcinoma cell line, KB-Cl. Four dihydropyridine analogues completely reversed the resistance, three lowered the resistance, and three had little effect. The radioactive photoactive dihydropyridine calcium channel blocker, [3H]azidopine, photolabels P-glycoprotei...

OBJECTIVES Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel 1, 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats. MATERIALS AND METHODS Four 1, 4-dihydropyridi...

in this study the anticonvulsant effect of two dihydropyridine derivatives [diethyl -1,4- dihydro -2,6- dimethyl -4-(4- fluoro benzyl-2- methylthio -5- imidazolyl)-3,5- pyridine dicarboxilat ( a ) and diethyl -1,4- dihydro -2,6- diethyl -4-(4- fluoro benzyl-2- methylthio -5- imidazolyl)-3,5- pyridine dicarboxilat ( b )] by pentylenetetrazole (ptz) and electroshock in mice was evaluated. the lat...

In the title compound, C(18)H(22)N(2)O(4), the dihedral angle between the two rings is 87.90 (6)°. The mean devation of the atoms in the dihydropyridine plane is 0.082 (3) Å. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, generating chains.