abstract: in a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely urazoles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. the structures of these compounds have been investigated by spectral data. the synthesized compounds...

Since the discovery by Knoevenagel [1] that doubly activated carbonic acids (CH-acids) react with carbonyl compounds to give the corresponding conjugated olefins, this reaction has been widely used in organic synthesis as an important method for carbon —carbon bond formation [2, 3). The conden­ sation of 1,3-dicarbonyl compounds with monocar­ bonyl compounds usually leads to a,/3-unsaturated pr...

A sensitive liquid chromatograph/tandem mass spectrometric technique (LC/MS/MS) was applied to determine aliphatic and aromatic carbonyl compounds in ambient air. Traces of the carbonyl compounds were sampled by passing through a Sep-Pak DNPH-silica cartridge. Their derivatives were thus eluted with acetonitrile, separated by reversed-phase liquid chromatography and determined by quadrupole tan...

Naphthalene, anthracene and phenanthrene are metabolized in rats and rabbits to 1:2-dihydroxy compounds which have been proved to be 1:2dihydro-1:2-diols (Young, 1950; Boyland, 1950). In the benzene series, an o-dihydroxy compound, 4-chlorocatechol, is a major metabolite of chlorobenzene in the rabbit (Spencer & Williams, 1950; Smith, Spencer & Williams, 1950). Many monosubstituted benzenes, e....

Potential biological properties of newly synthesized single and double alkyl chain N-oxides of tertiary amines (NTA) were studied. Individual compounds in each of the series had alkyl chains of different length. Various experiments were performed to determine a mechanism of the interaction between NTA and model and biological membranes. These were measurements of hemolytic efficiencies of NTA (...

Introduction Conclusions References

Described herein is the development of a continuous flow, solid-phase triphenylphosphine (PS-PPh3) assisted protocol to facilitate in situ coupling reciprocal pairs halogen and carbonyl functionalised molecular by Wittig olefination within 15 mins. The entails injecting single solution (1 : 1 CHCl3 EtOH) containing halogenated carbonyl-based substrates into continuously flowing stream EtOH 1), ...

recent studies have indicated that 1, 4-dihydropyridine-3, 5-dicarboxamidederivativesshow significant anti-tubercular activity. in this research, new derivatives of 1, 4-dihydropyridine were designed and synthesized using hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoylwere substituted at c-3 and c-5 positions of the dhp ring.in addition, 4 (5)-chloro-2-methyl-5 (...