Background Multicellular pattern formation plays an important role in developmental biology, cancer metastasis and wound healing. While many physical factors have been shown to regulate these multicellular processes, the role of ECM micro-to-meso scale geometry has been poorly understood in 3D collective cancer invasion. Results We have developed a mechanical-based strategy, Diskoid In Geomet...

Collagen- and fibrin-based gels are extensively used to study cell behaviour. However, 2D-3D and collagen-fibrin comparisons of gene expression, cell shape and mechanotransduction, with an in vivo reference, have not been reported. Here we compared chick tendon fibroblasts (CTFs) at three stages of embryonic development with CTFs cultured in collagen- or fibrin-based tissue engineered construct...

Accurate wound assessment is a critical task for patient care and health cost reduction at hospital but even still worse in the context of clinical studies in laboratory. This task, completely devoted to nurses, still relies on manual and tedious practices. Wound shape is measured with rules, tracing papers or rarely with alginate castings and serum injection. The wound tissues proportion is al...

Health care professionals responsible for patients with complex wounds need a particular level of expertise and education to ensure optimum wound care. However, uniform education for those working as wound care nurses is lacking. We aimed to reach consensus among experts from six European countries as to the competencies for specialised wound care nurses that meet international professional exp...

Defined biomimetic three-dimensional (3D) matrices are needed to decipher the complex cellular signalling during wound healing at high resolution in vitro. Soluble factors like TGF-β1 and adhesion promoting structural components of the extracellular matrix (ECM) are known to be key regulators of fibroblast behaviour. The ECM component fibronectin (FN) bears a complex function as adhesion promot...

T he process of debridement is an important step in the preparation of the wound bed in chronic wounds. Ways in which wound debridement can be achieved include surgical, sharp, mechanical, enzymatic and autolytic debridement. Expert opinion and clinical experience suggest that removal of the material such as necrotic tissue and fibrinous slough from the surface of a wound is necessary for the p...

Microchannel liquid cooling is a promising technique to handling the high temperature problem of threedimensional (3D) processors. There have been a few works which made initial attempts to optimize liquid cooling by utilizing non-uniformly distributed channels, variable flow rate, wider channels, and Dynamic Voltage and Frequency Scaling (DVFS) combined with thread migration mechanisms. Althou...

Various properties of 3D shape are concentrated at medial locations and can be measured efficiently and robustly using populations of medial primitives that we call core atoms. These primitives are based on a graded measurement of medialness with scaled apertures. Analysis of them yields a medial cloud called a core. The local scale, orientation, and dimensionality of a core constitute fundamen...

OBJECTIVE To investigate the ability of high-resolution MRI to determine composition and microanatomy of atherosclerosis in mouse aortic root and brachiocephalic artery. METHODS AND RESULTS Aortic root and brachiocephalic arteries of apolipoprotein E knockout (apoE-/-) mice fed Western diet for 10, 20, or 30 weeks were imaged ex vivo (11.7 T; 3D multiecho sequence; resolution 47x47x62.5 micro...

Technology scaling and increasing power densities have led to a transition from single-core to multi-core processors, and the trend is now moving towards many-core architectures. Hundreds of millions of transistors can now be integrated on a single chip, however, they cannot be fully exploited due to interconnect/memory latency, power consumption, and yield related challenges. 3D integration is...