Kappa opioid receptor (KOR) desensitization was previously shown to follow agonist-dependent phosphorylation of serine 369 by G-protein receptor kinase (GRK) and beta-arrestin binding in transfected cells. To study the in vivo effects induced by phosphorylation of KOR(S369), C57Bl/6 mice were administered single or repeated doses of the KOR agonist, U50,488, and isolated brain glycoprotein was ...

BACKGROUND In people with chronic illnesses, self-management education can reduce anxiety and depression. Those benefits, however, decay over time. Efforts have been made to prevent or minimize that "decay of impact", but they have not been based on information about the decay's characteristics, and they have failed. Here we show how the decay's basic characteristics (prevalence, timing, and ma...

p67(phox) is the paramount cytosolic regulator of the superoxide-generating Nox of phagocytes, by controlling the conformation of the catalytic component, Nox2. The initiating event of this process is a protein-protein interaction between p67(phox) and the part of Nox2 protruding into the cytosol, known as the dehydrogenase region. The aim of this study was to identify and characterize region(s...

São Carlos Institute of Physics, University of São Paulo, São Carlos SP, PO Box 369, 13560-970, Brazil. Scientific Computing Group http://scg.ifsc.usp.br Department of Mathematics, University of California Irvine, 340 Rowland Hall, Irvine, CA 92697, USA Institute of Mathematics and Computer Science, University of São Paulo, USP, Avenida Trabalhador são-carlense, 400, 13566-590, São Carlos, SP, ...

Blackwell Publishing, 9600 Garsington Road, Oxford OX4 2DQ, UK and 350 Main Street, Malden, MA 02148, USA. British Journal of Educational Technology Vol 38 No 2 2007 369–372 doi:10.1111/j.1467-8535.2006.00644.x Blackwell Publishing Ltd.Oxford, UKBJETBritish Journal of Educational Technology0007-1013British Educational Communications and Technology Agency, 20062006382369372Colloquium ColloquiumB...