OBJECTIVE To study the effect of chronic noise exposure on expression of N-methyl-D-aspartic acid receptor 2B (NR2B) and tau phosphorylation in hippocampus of rats. METHODS Twenty-four male SD rats were divided in control group and chronic noise exposure group. NR2B expression and tau phosphorylation in hippocampus of rats were detected after chronic noise exposure (100 dB SPL white noise, 4 ...

Arachidonic acid at micromolar concentrations produced a drastic increase of the generation of reactive oxygen species (ROS) in rat hepatoma AS-30D cells cultivated in vitro along with an increase in the incidence of apoptotic cell death. Both processes were prevented by trolox, a water-soluble tocopherol derivative, and tempol, a known antioxidative agent. A synthetic hybrid of lipoic acid and...

The influence of the protein content of the diet on glucose concentration (denoted by fluorescence intensity) and body weight was studied in the white rat. Rats of 30d of age received ad lib. a control diet containing 15% crude protein (Pl5), or a diet containing 23% crude protein (P23) or 35% crude protein (P35) and a fourth group of rats (P8) received the 8% crude protein contained diet. Afte...

The aim of this work was to prepare and evaluate the physicochemical properties film-forming polymeric solutions containing madecassoside asiaticoside. stability in vitro release were also investigated. Hypromellose E5 Eudragit® NE 30D used as agents. Glycerin a plasticizer. Ethanol is solvent for shortening film drying. best formulations composed 5 % hypromellose E5, glycerin, ethanol, Centell...