We have previously obtained, by exposure to near continuous increasing concentrations of cisplatin, a panel of human ovarian cancer cell lines that exhibit a wide range of primary resistance to the drug (9- to > 400-fold). These cells had strikingly increased (4- to 50-fold) levels of glutathione (GSH) as compared with the drug-sensitive cells of origin (A. K. Godwin et al., Proc. Natl. Acad. S...

Introduction: Acute pancreatitis is an inflammatory condition of the pancreas which begins in pancreatic acinar cells and triggers local inflammation that may progress to systemic inflammatory response (SIRS) and causing distant organ involvement and its function and ending up with multiple organ dysfunction syndromes (MODS). Aim: To find out the effectiveness of addition of Ulinastatin to stan...

BACKGROUND Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately compared. METHODS At 118 sites, patients who had HCV genotype 1 infection and who had not previously been treated were randomly assigned to undergo 48 weeks of treatment...

OBJECTIVES To assess the association between petrochemical exposure and spontaneous abortion, a retrospective epidemiological study in a large petrochemical complex in Beijing, China was conducted. METHODS Plant employment records identified 3105 women who were married, were 20-44 years of age, and had never smoked. Of those, 3070 women (98.8%) reported at least one pregnancy. From this group...

The rise of high-throughput sequencing techniques provides the unprecedented opportunity to analyse controversial phylogenetic relationships in great depth, but also introduces a risk of being misinterpreted by high node support values influenced by unevenly distributed missing data or unrealistic model assumptions. Here, we use three largely independent phylogenomic data sets to reconstruct th...

TOPIC: Cardiovascular Disease TYPE: Medical Student/Resident Case Reports INTRODUCTION: Sympathectomy has been used since the 1960s for treatment of refractory ventricular tachycardia (VT)(1). However, procedure not studied with a randomized controlled trial; clear indications and outcome data remain unclear. In this case report, we describe use sympathectomy in patient VT storm provoked by thy...

How do people typically form opinions and make choices about national matters? What factors infl uence how people behave in the political realm? The majority of work on these questions in psychology and political science has emphasized the role of consciously accessible infl uences on political behavior, such as political party affi liation and an assortment of principles and values. Although t...

Personalized medicine aims to treat patients individually according their biological and molecular features by directly targeting tumor-specific markers. Gastrointestinal cancers (GIC), despite different treatment strategies, still have a high recurrence mortality rate. Like in all other cancers, targeted therapies are also clinical trials for GICs, but the monitorization of therapy success nee...