In mammalian cells, splice junctions play a dual role in mRNA quality control: They mediate selective nuclear export of mature mRNA and they serve as a mark for mRNA surveillance, which subjects aberrant mRNAs with premature termination codons to nonsense-mediated decay (NMD). Here, we demonstrate that the protein RNPS1, a component of the postsplicing complex that is deposited 5' to exon-exon ...

Ribosomes play a critical role in maintaining cellular proteostasis. The binding of messenger RNA (mRNA) to the ribosome regulates kinetics protein synthesis. To generate an understanding structural, mechanistic, and dynamical features mRNA recognition ribosome, we have analysed mRNA-protein interactions through structural comparison ribosomal complex presence absence mRNA. do so, compared 3-Di...