The global production of fish oil is around one million tonnes. This production is expected to be maintained. Rich in long-chain omega-3 fatty acids, especially EPA and DHA, it can supplement diets inadequate in these fatty acids such as those in many Western countries. Farmed fish, especially oily fish such as salmonids fed on fish oil provide an excellent source of these acids. Fish oil can b...

background: it has been shown that serum total homocysteine (hc) is a risk factor for vascular disease which characterizes endothelial damage in the general and in the end-stage renal disease (esrd) population as well. whether n-3 polyunsaturated fatty acids decrease homocysteine (hcy) level has been a subject of controversy. methods: renal transplant patients were randomized in 2 groups and re...

We examined whether a low amount of dietary long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) modulated phosphatidylinositol 3'-kinase (PI 3-kinase) activity and downstream Akt phosphorylation differently in normal or insulin-resistant rats. Rats were fed for 28 days with either a control diet containing 14.6% of metabolizable energy (ME) as peanut-rape oil (PR) or an n-3 diet where 4.9%...

The n-3 fatty acids of fish and fish oil have great potential for the prevention and treatment of patients with coronary artery disease. Unlike many of the pharmaceutical agents used in patients with coronary artery disease that have just a single mechanism of action, the eicosapentaenoic and docosahexaenoic acids of fish oil have multifaceted actions. One of their most important effects is the...

The present study reports results from two investigations to determine effects of a 6-week period of moderate n-3 fatty acid supplementation (2.7 g/d) on fasting and on postprandial triacylglycerol and metabolic hormone concentrations in response to standard test meals. In the first study postprandial responses were followed for 210 min after an early morning test meal challenge; in the second ...

Norepinephrine stimulates lipolysis and concurrently inhibits insulin-stimulated leptin secretion from white adipocytes. To assess whether there is a cause-effect relationship between these two metabolic events, the effects of fatty acids were investigated in isolated rat adipocytes incubated in buffer containing low (0.1%) and high (4%) albumin concentrations. Palmitic acid (1 mM) mimicked the...

Dietary fat is an important source of energy for mammals, but it was not until the advent of intravenous feeding that the importance of essential fatty acids was widely accepted. “Essential” fatty acids were identified in research with patients on total parenteral nutrition or with malabsorption syndromes, as they developed dermatitis, changes in visual and neural function, and immunomodulatory...

Background: Polyunsaturated n-3 fatty acids (n-3 PUFAs) are reported to protect against high fat diet-induced obesity and inflammation in adipose tissue. Here we aimed to investigate if the amount of sucrose in the background diet influences the ability of n-3 PUFAs to protect against diet-induced obesity, adipose tissue inflammation and glucose intolerance. Methodology/Principal Findings: We f...