Objective: Insulin resistance (IR) is the major cause in Type 2 diabetes mellitus (T2DM). Expression of some miRNAs can be changed in response to a drug treatment for IR, and used as the biomarker in IR. This study set out to determine the effect of cinnamon extract (cinnamaldehyde) on some miRNAs expression in IR adipocytes. Materials and Methods: In this In-vitro study the 3T3L1 cells were e...

Abstract Background: A unique feature of muscle during aging, obesity and type 2 diabetes is the appearance adipose tissue between skeletal fibers, intramuscular (IMAT). IMAT generally associated with systemic insulin resistance, decreased strength and, in older adults, impaired mobility. large body work over last years have addressed origin IMAT. Skeletal contains preadipocyte progenitors term...

Abstract Background Gastric cancer (GC) is among the most common and deadliest cancers globally. Many long non-coding RNAs (lncRNAs) are key regulators of GC pathogenesis. This study aimed to define role HOXA-AS3 in this oncogenic context. Methods Levels expression were quantified via qPCR. The effects knockdown on cells function evaluated vitro using colony formation assays, wound healing assa...

Westerbork Radio Synthesis Telescope observation of the galaxy VV 29=Arp 188=UGC 10214 shows that there are at least three distinct dynamical components whose kinematics can be traced in 21cm line emission. The system appears to be the result of a galaxy-galaxy interaction. We identify a sufficient number of dynamical elements containing baryons (stars and neutral gas) that there is no compelli...

Biomarkers that can facilitate disease detection, staging and prediction of outcome are highly desirable to improve survival and to help determine optimized treatment for colorectal cancer patients. microRNAs (miRNAs) are small non-coding RNAs that play a crucial role in gene regulatory networks. The deregulation of miRNA expression has been found in several types of cancer and may represent a ...

Fibrosis refers to the accumulation of excess extracellular matrix (ECM) components and represents a key feature of many chronic inflammatory diseases. Unfortunately, no currently available treatments specifically target this important pathogenic mechanism. MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress target gene expression and the development of miRNA-based...

The sources of ipsilateral projections from the hippocampal formation, the presubiculum, area 29a-c, and parasubiculum to medial, orbital, and lateral prefrontal cortices were studied with retrograde tracers in 27 rhesus monkeys. Labeled neurons within the hippocampal formation (CA1, CA1', prosubiculum, and subiculum) were found rostrally, although some were noted throughout the entire rostroca...

BACKGROUND AND AIMS Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming. While a major epigenetic code controlling the coordinated regulation of a whole transcriptional profile is guaranteed by DNA methylation, DNA methyltransferase (DNMT) a...